Mechanistic toxicology : the molecular basis of how chemicals disrupt biological targets
by
Boelsterli, Urs A., 1948-
Title
:
Mechanistic toxicology : the molecular basis of how chemicals disrupt biological targets
Author
:
Boelsterli, Urs A., 1948-
ISBN
:
9780849372728
Edition
:
2nd ed.
Publication Information
:
Boca Raton : CRC Press, 2007.
Physical Description
:
399 s.
Contents
:
Types of toxic responses -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Interactions of xenobiotics with ion transporters -- Nuclear receptor-mediated toxicity -- Activation or disruption of cellular signal transduction by xenobiotics -- Disruption of mitochondrial function and mitochondria-mediated toxicity -- Novel mechanisms derived from systems toxicology.
Subject Term
:
Toksikoloji -- yöntemler
Moleküler Biyoloji -- yöntemler
Sinyal İletimi
Ksenobiotikler -- farmacokinetiks
Ksenobiotikler -- zehirlilik
Toxicology -- methods
Molecular Biology -- methods
Signal Transduction
Xenobiotics -- pharmacokinetics
Xenobiotics -- toxicity
Library | Material Type | Item Barcode | Shelf Number | [[missing key: search.ChildField.HOLDING]] | Status |
---|
Health Sciences Library | Book | 7.2/12/399511 | QV 602 B671 2007 | | Sağlık Bilimleri Genel Koleksiyon |