Colleen Gibson (Sarah Jessica Parker), Dick (Johnny Knoxville)'i gerçekten sevmektedir. Ancak bir falcının (Teri Garr), erkek arkaşının onu aldattığına ikna etmesi üzerine bu ilişkiye bir son vermeye karar verir. Ama ne yazık ki onu tehdit etmek üzere kullandığı silah kazara ateş alır. Bu arada Colleen, kimseyi öldürmeyi beceremeyen kiralık katil Daniel (Harry Connick, Jr.) ile çıkmaya başlar. Colleen Daniel'in aslında Dick'i öldürmek üzere kiralandığını öğrendiğinde keşfeder. İşin içine mafyanın da girmesiyle olaylar arap saçına döner.

Life Without Dick is a hilarious romentic comedy about love and murder starring two-time Golden Globe winner (Best Actress) for TV's Sex and the City, Sarah Jessic Parker and two-time Grammy Award winning musician and actor, Harry Connick Jr. When Colleen Gibson (Parker), heir to the Rosie Red Grapefruit fortune discovers her boyfriend Dick Rasmusson (Johnny Knoxville) is planning to leave her, she accidentally kills him. However, Dick was already in line to be killed by reluctant Irish hit man Daniel Gallagher (Connick Jr.), who disillusioned with his day job, dreams of pursuing his passion for singing instead. When Colleen and Daniel meet, sparks fly and Daniel is so impressed by Colleen's talent for wiping people out, he enlists her help in his other assignments. As Colleen and Daniel live a Life Without Dick, a strange mix of lies, mistaken identity and a junkyard full of bodies test their love and teach them both the value of trust.