ch. 1. Scientific and regulatory overview of process analytical technology in bioprocess / Rakhi B. Shah ... [et al.] -- ch. 2. Strategic vision for integrated process analytical technology and advanced control in biologics manufacturing / Melissa M. St. Amand ... [et al.] -- ch. 3. Multivariate techniques in biopharmaceutical process development / Jeremy S. Conner -- ch. 4. Analysis, monitoring, control, and optimization of batch processes : multivariate dynamic data modeling / Theodora Kourti -- ch. 5. Multivariate data analysis in biopharmaceuticals / Joydeep Ganguly ... [et al.] -- ch. 6. Process analytical technology advances and applications in recombinant protein cell culture processes / Ana Veronica Carvalhal and Victor M. Saucedo -- ch. 7. Process analytical technology applied to raw materials / Erik Skibsted -- ch. 8. Process analysis technology for enhanced verification of bioprocess system cleaning / Peter K. Watler ... [et al.] -- ch. 9. Cell culture process analytical technology multiplexing near-infrared / Mariana L. Fazenda, Linda M. Harvey, and Brian McNeil -- ch. 10. Process analytical technology for bioseparation unit operations / Anurag S. Rathore, Vishal Ghare, and Rahul Bhambure -- ch. 11. Process analytical technology use in biofuels manufacturing / Pedro Felizardo, Jos ̌C. Menezes, and M. Joana Neiva-Correia -- ch. 12. Application of microreactors for innovative bioprocess development and manufacturing / Seth T. Rodgers and A. Peter Russo -- ch. 13. Real-time monitoring and controlling of lyophilization process parameters through process analytical technology tools / Feroz Jameel and William J. Kessler -- ch. 14. Process analytical technology's role in operational excellence / Fetanet Ceylan Erzen and Manbir Sodhi -- ch. 15. Conclusions, current status, and future vision of process analytical technology in biologics / Duncan Low and Ray Chrisman.