Rational for Focal Therapy -- Concept of Index lesion -- Definition and Principles of Focal Therapy -- Eligibility for Focal Therapy: Patient Selection -- Imagingfor Focal Therapy -- Biopsies strategy -- Focal Cryotherapy -- Focal HIFU -- Focal Brachytherapy -- Focal PhotoDynamic Therapy -- Focal Laser Thermal Therapy -- Cyberknife Focal Therapy -- New Energies -- Follow-up after Focal Therapy -- Failure or Recurrence Management -- Focal Therapy Limitations -- Perspective -- Conclusion.