1 The genesis of the edge-to-edge technique -- 2 The principle: from computational model to clinical validation -- 3 Technical aspects: sternotomy and minimally invasive surgery -- 4 Is there a role for the edge-to-edge technique in robotic mitral valve repair? -- 5 Echocardiographic assessment of a double orifice mitral valve: tips and tricks.- 6 The early phase of clinical application: lessons learned.- 7 Early and long-term results of the EE repair -- 8 Transaortic edge-to-edge technique in patients with hyperthrophic obstructive cardiomyopathy -- 9 Mitral stenosis after EE repair: is it an issue?.- 10 Current surgical indications and contraindications.- 11 The case of surgical EE repair without annuloplasty: now we know -- 12 Evolution of EE repair: from surgery to percutaneous -- 13 State of the art in Mitraclip therapy: who, when and how -- 14 Clinical results of the percutaneous EE repair: lights and shadows -- 15 Future perspectives on percutaneous EE repair -- 16 Conclusions.