Chapter 1. Background and Overview -- Part I. Performance Analysis Methods: Communication Analysis -- Chapter 2. Fast Communication Trace Collection -- Chapter 3. Structure-Based Communication Trace Compression -- Part II. Performance Analysis Methods: Memory Analysis -- Chapter 4. Informed Memory Access Monitoring -- Part III. Performance Analysis Methods: Scalability Analysis -- Chapter 5. Graph Analysis for Scalability Analysis -- Chapter 6. Performance Prediction for Scalability Analysis -- Part IV. Performance Analysis Methods: Noise Analysis -- Chapter 7. Lightweight Noise Detection -- Chapter 8. Production-Run Noise Detection -- Part V. Performance Analysis Framework -- Chapter 9. Domain-Specific Framework for Performance Analysis -- Chapter 10. Conclusion and Future Work.