Foreword -- Preface -- Part I. The Host Immune Response -- Phenotypes -- The Dysregulated Host Response -- What is Cytokine Storm? -- Hemophagocytic Lymphohistiocytosis -- Extracorporeal Circulation Related Immune response -- Vasoplegic Shock -- Part II. Assessing Dysregulated Immune Response at the Bedside -- Pro- and anti-inflammatory biomarkers -- How to interpret procalcitonin? -- Assessment of the macro-, and microcirculation -- Part III. Dysregulated Immune Response and organ dysfunction -- Heart and circulation -- Brain -- Kidneys -- Liver -- Hemostasis -- The muscles -- Part IV. Modulating the immune response -- The Role of Steroids -- Why did Anti-Cytokine Therapies Fail in the Past? -- Extracorporeal cytokine removal.