Section I: Introductory Materials -- Regulatory actions of glucocorticoid hormones: from organisms to mechanisms.-  Molecular Biology of  Glucocorticoid Signaling.-Mechanisms of Glucocorticoid-regulated Gene Transcription -- Clinical Perspective: What do Addison and Cushing tell us about Glucocorticoid Action? -- Section II: Effects of Glucocorticoids in Metabolism -- Regulation of Glucose Homeostasis by Glucocorticoids -- How do Glucocorticoids Regulate Lipid Metabolism? -- Glucocorticoids and Skeletal Muscle -- Section III: Specific Effects of Glucocorticoids on Tissues -- Glucocorticoid- induced osteoporosis -- Effects of Glucocorticoids on Immune System -- Glucocorticoids and the brain: neural mechanisms regulating the stress response -- Glucocorticoid Regulation of Reproduction -- Glucocorticoids and the lung -- Glucocorticoids and the Cardiovascular System -- Glucocorticoids and Cancer -- Section IV: Miscellaneous Topics -- Animal Models of Altered Glucocorticoid Signaling -- The Dehydrogenase Hypothesis -- Conclusions and Future Directions.