Part I Biochemistry, molecular biology and chemistry -- 1 H2Ssynthesizing enzymes: biochemistry and molecular aspects -- Part II Molecular mechanisms of action -- 2 Sulfhydration and H2S -- 3 Persulfide formation and H2S -- Part III Cardiovascular system -- 4 H2S and blood vessels - an overview -- 5 Hydrogen sulfide and urogenital tract -- 6 H2S - cardiac function and cardiac disease -- 7 H2S and platelets - a possible role in thrombosis? -- Part IV Inflammation and inflammatory disease -- 8 H2S and inflammation  - an overview -- 9 H2S and neuroinflammation -- Part V H2S and the nervous system -- 10 Brain, learning and memory: role in neurodegenerative diseases -- 11 H2S and pain - inflammatory and neuropathic -- Part VI H2S, angiogenesis and cancer -- 12 H2S and colon cancer -- 13 The role of H2S in cancer and tumor development -- Part VII H2S and ageing -- 14 H2S - a new approach to lifespan enhancement and healthy aging? -- Part VIII H2S, measurement and possible therapeutics? -- 15 Measurement of H2S - probes comes of age? -- 16 S-propargylcysteine - a novel H2S donor with therapeutic potential -- 17 Mitochondria-targetted sulfide donors -- 18 Medicinal chemistry - insights into the development of novel H2S donors.