Preface -- Basics of sleep and wakefulness. Genetic dissection of sleep homeostasis -- Sleep, sleep deprivation and gene expression -- Sleep and synaptic homeostasis -- Sleep and neuronal plasticity -- Sleep and adult neurogenesis: implications for cognition and mood -- Sleep & memory: molecular mechanisms -- Sleep & memory in birds -- MRI studies of sleep and memory in humans -- Sleep & memory: cognitive function in humans -- Sleep and cognition in ageing and dementia -- The adenosine system, caffeine, and performance.- Orexin/Hypocretin regulation of arousal and optogenetics -- Sleep, stress and arousal -- Sleep and emotional regulation -- Sleep and psychiatric disorders (PTSD, anxiety, aggression, schizophrenia) -- Sleep disruption as a causal factor in depression -- Sleep deprivation therapy for depression -- Pharmacology of sleep and sleep disorders.