Preface -- Part I: Introduction -- Chapter 1: Overview of Metal-on-Metal Implants -- Chapter 2: Bearing Surfaces for Joint Replacement: New Materials or New Problems? -- Part II: Clinical -- Chapter 3: Outcome Studies for Metal-on-Metal Bearings: What Evidence-Based Medicine Tells Us -- Chapter 4: Metal Reactivity: Its Influence on Primary and Revision Outcomes -- Chapter 5: Are metal ion levels a trigger for surgical intervention? -- Chapter 6: Metal Sensitivity: Is it possible to Determine Clinically? -- Part III: Biology -- Chapter 7: Wound healing, chronic inflammation, and immune responses -- Chapter 8: Benign Responses to Orthopaedic Implants: Really? -- Chapter 9: What does the Histology Tell Us? -- Part IV: Biomechanics -- Chapter 10: Why metal-on-metal -what laboratory tests have shown us -- Chapter 11: What do the Retrievals really tell us? -- Future Directions.- Index.