chapter 1 The History of Multiple Sclerosis / chapter 2 The Epidemiology of Multiple Sclerosis / chapter 3 The Genetics of Multiple Sclerosis / chapter 4 Experimental Models of Virus-Induced Demyelination / chapter 5 Evidence for a Viral Etiology of Multiple Sclerosis / chapter 6 Experimental Models of Autoimmune Demyelination / chapter 7 Evidence for Immunopathogenesis / chapter 8 Autoantibodies in Demyelinating Disease / chapter 9 Clinical Features / chapter 10 Cognitive Impairment in Multiple Sclerosis / chapter 11 Loss and Restoration of Impulse Conduction in Disorders of Myelin / chapter 12 Pathology of Multiple Sclerosis / chapter 13 Axonal Injury in Multiple Sclerosis / chapter 14 Cerebrospinal Fluid / chapter 15 Laboratory Tests: Evoked Potentials / chapter 16 Neuroimaging and the Use of Magnetic Resonance in Multiple Sclerosis / chapter 17 The Natural History of Multiple Sclerosis / chapter 18 Prognostic Factors in Multiple Sclerosis / chapter 19 Therapeutic Considerations: Rating Scales / chapter 20 Therapeutic Considerations: Treatment of the Acute Exacerbation / chapter 21 Interferon--1b: Prophylactic Therapy in Multiple Sclerosis / chapter 22 Therapeutic Considerations: Prophylactic Therapy with Interferon--1a / chapter 23 Prophylactic Therapy—Glatiramer Acetate (Copaxone) / chapter 24 Treatment of Multiple Sclerosis with Intravenous Immunoglobulin / chapter 25 Immunosuppressive Drugs / chapter 26 Treatment of Multiple Sclerosis: Bone Marrow Reconstitution, Total Lymphoid Irradiation, and Plasma Exchange / chapter 27 Symptomatic Therapy / chapter 28 Symptomatic Treatment and Rehabilitation in Multiple Sclerosis / chapter 29 Experimental Therapies with T-Cell Vaccines, Oral Myelin, and Monoclonal Antibodies in Multiple Sclerosis / chapter 30 Future Immunotherapies