1. Overview on opioid-induced hyperalgesia / Jianren Mao -- 2. Cellular mechanisms underlying morphine analgesic tolerance and hyperalgesia / Hiroshi Ueda -- 3. Overview on clinical features of opioid-induced hyperalgesia / Martin S. Angst, Larry F. Chu, and J. David Clark -- 4. Clinical assessment tools : quantitative sensory testing / Robert R. Edwards -- 5. Opioid tolerance, dependence, and hyperalgesia / Jane C. Ballantyne -- 6. Challenging clinical issues on the interaction between addiction and hyperalgesia / Walter Ling and Peggy Compton -- 7. Practical management of opioid-induced hyperalgesia in the primary care setting / Bill McCarberg -- 8. Managing opioid-induced hyperalgesia in the perioperative period / Matthew Crooks and Steven P. Cohen -- 9. Role of ketamine in managing opioid-induced hyperalgesia / Yakov Vorobeychik -- 10. Role of opioid rotation and tapering in managing opioid-induced hyperalgesia / Howard S. Smith -- 11. Role of adjuvant medications in managing opioid-induced hyperalgesia / David Giampetro and Yakov Vorobeychik -- 12. Clinical implications of opioid-induced hyperalgesia / Jianren Mao.