part PART I: Concepts -- chapter 1 Skin Permeability -- chapter 2 Occlusion and Barrier Function -- chapter 3 Percutaneous Absorption of Complex Chemical Mixtures -- chapter 4 Anatomical Factors Affecting Barrier Function -- chapter 5 Percutaneous Absorption: Role of Lipids -- chapter 6 Percutaneous Absorption: Short-Term Exposure, Lag Time, Multiple Exposures, Model Variations, and Absorption from Clothing -- chapter 7 Chemical Partitioning into Powdered Human Stratum Corneum: A Useful In Vitro Model for Studying Interaction of Chemical and Human Skin -- chapter 8 Sensitive Skin -- chapter 9 Transdermal Drug Delivery System-An Overview -- chapter 10 Iontophoresis -- chapter 11 Irritant Dermatitis (Irritation) -- chapter 12 Allergic Contact Dermatitis -- chapter 13 Irritant Contact Dermatitis versus Allergic Contact Dermatitis -- chapter 14 Molecular Basis of Allergic Contact Dermatitis -- chapter 15 System Contact Dermatitis -- chapter 16 Permeability of Human Skin to Metals and Paths for Their Diffusion -- chapter 17 Photoirritation (Phototoxicity, Phototoxic Dermatitis) -- chapter 18 Chemically Induced Scleroderma -- chapter 19 Chemical Agents that Cause Depigmentation -- chapter 20 Sulfar Mustard: A Chemical Vesicant Model -- chapter 21 Carcinogenesis: Current Trends in Skin Cancer Research -- chapter 22 Retinoids and Their Mechanisms of Toxicity -- chapter 23 Skin Disorders Caused by Cosmetics in China -- chapter 24 Drug Induced Ocular Phototoxicity -- chapter 25 Water: Is It an Irritant? -- chapter 26 Sodium Lauryl Sulfate in Dermatotoxitcology -- chapter 27 Barrier Creams -- part PART II: Methods -- chapter 28 Methods for In Vitro Percutaneous Absorption -- chapter 29 Tape Stripping Method and Stratum Corneum -- chapter 30 Pecutaneous Absorption of Hazardous Substances from Soil and Water -- chapter 31 Isolated Perfused Porcine Skin Flap -- chapter 32 Physiologically Based Pharmacokinetic Modeling -- chapter 33 Methods for In Vitro Skin Metabolism Studies -- chapter 34 Transdermal Drug Delivery Systems: Dermatologic and Other Adverse Reactions -- chapter 35 Predictive Toxicology Methods for Transdermal Delivery Systems -- chapter 36 Animal, Human and In Vitro Test Methods for Predicting Skin Irritation -- chapter 37 Analysis of Structural Change in Intercellular Lipids of Human Stratum Corneum Induced by Surfactants: Electron Paramagnetic Resonance (EPR) Study -- chapter 38 Test Methods for Allergic Contact Dermatitis in Animals -- chapter 39 Test Methods for Allergic Contact Dermatitis in Humans -- chapter 40 Immunoadjunants in Prospective Testing for Contact Allergens -- chapter 41 The Local Lymph Node Assay -- chapter 42 Contact Urticaria and the Contact Urticaria Syndrome (Immediate Contact Reactions) -- chapter 43 An Optimized In Vitro Approach to Assess Skin Irritation and Phototoxicity of Topical Vehicles -- chapter 44 Photoirritation (Phototoxicity) Testing in Humans -- chapter 45 Measuring and Quantifying Ultraviolet Radiation Exposures -- chapter 46 Use of Pig Skin Preparations in Novel DIffusion Cell Arrays to Measure Skin Absorption and to Evaluate Potential Chemical Toxicity -- chapter 47 Determination of Subclinical Changes of Barrier Function -- chapter 48 Assessing the Validity of Alternative Methods of Toxicity Testing -- chapter 49 Animal Models for Immunologic and Nonimmunologic Contact Urticaria -- chapter 50 Diagnostic Tests in Dermatology: Patch and Photopatch Testing and Contact Urticaria -- chapter 51 Cosmetic Reactions -- chapter 52 Evaluating Efficacy of Barrier Creams: In Vitro and In Vivo Models -- chapter 53 Light-Induced Dermal Toxicity: Effects on the Cellular and Molecular Levels.