chapter 1. Introduction to the modeling and simulation-based systems engineering handbook / Daniele Gianni, Andrea D'Ambrogio, and Andreas Tolk -- chapter 2. Systems engineering, architecture, and simulation / Andreas Tolk and Taylor K. Hughes -- chapter 3. System modeling : principled operationalization of social systems using Presage2 / Sam Macbeth, Didac Busquets, and Jeremy Pitt -- chapter 4. Formal agent-based models of social systems / Il-Chul Moon -- chapter 5. On the evolution toward computer-aided simulation / Luiz Felipe Perrone -- chapter 6. Model-driven method to enable simulation-based analysis of complex systems / Paolo Bocciarelli and Andrea D'Ambrogio -- chapter 7. Collaborative modeling and simulation in spacecraft design / Volker Schaus, Daniel Ludtke, Philipp M. Fischer, and Andreas Gerndt -- chapter 8. Performance engineering of distributed simulation programs / Giuseppe Iazeolla and Alessandra Pieroni -- chapter 9. Reshuffling PDES platforms for multi/many-core machines : a perspective with focus on load sharing / Francesco Quaglia, Alessandro Pellegrini, and Roberto Vitali -- chapter 10. Layered architectural approach for distributed simulation systems : the SimArch case / Daniele Gianni -- chapter 11. Reuse-centric simulation software architectures / Olivier Dalle -- chapter 12. Conceptual models become alive with Vivid OPM : how can animated visualization render abstract ideas concrete? / Dov Dori, Sergey Bolshchikov, and Niva Wengrowicz -- chapter 13. Processes to support the quality of M&S artifacts / Jan Himmelspach and Stefan Rybacki -- chapter 14. Formal validation methods in model-based spacecraft systems engineering / Joost-Pieter Katoen, Viet Yen Nguyen, and Thomas Noll -- chapter 15. Modeling and simulation framework for systems engineering / Saikou Diallo, Andreas Tolk, Ross Gore, and Jose Padilla -- chapter 16. Liquid business process model collections / Wil M.P. van der Aalst, Marcello La Rosa, Arthur H.M. ter Hofstede, and Moe T. Wynn -- chapter 17. Web-based simulation using Cell-DEVS modeling and GIS visualization / Sixuan Wang and Gabriel Wainer.