chapter 1 An Overview of Scale-Up in Preparative Chromatography / chapter 2 Interaction of Mass Transfer and Fluid Mechanics / chapter 3 Optimization of Preparative Separations / chapter 4 Engineering Aspects of Ion-Exchange Chromatography / chapter 5 A Simple Approach to Design and Control of Simulated Moving Bed Chromatographs -- chapter 6 Large-Scale Ion-Exchange Chromatography: A Comparison of Different Column Formats -- chapter 7 Development and Operation of a Cation-Exchange Chromatography Process for Large-Scale Purification of a Recombinant Antibody Fragment -- chapter 8 Case Study: Capacity Challenges in Chromatography-Based Purification of Plasmid DNA -- chapter 9 Case Study: Purification of an IgG1 Monoclonal Antibody / chapter 10 Case Study: Normal Phase Purification of Kilogram Quantities of a Synthetic Pharmaceutical Intermediate -- chapter 11 Case Study: Development of Chromatographic Separation to Remove Hydrophobic Impurities in Alatrofloxacin -- chapter 12 Case Study: Process Development of Chromatography Steps for Purification of a Recombinant E. coli Expressed Protein.