ch. 1. Evolution, regulation, and disruption of homeostasis and its role in carcinogenesis / Alexander R.A. Anderson. [et al.] -- ch. 2. Cancer cell : linking oncogenic signaling to molecular structure / Jeremy E. Purvis. [et al.] -- ch. 3. Has cancer sculpted the genome? : modeling linkage and the role of tetraploidy in neoplastic progression / Carlo C. Maley, Walter Lewis, and Brian J. Reid -- ch. 4. Catastrophes and complex networks in genomically unstable tumorigenesis / Ricard V. Sole -- ch. 5. A stochastic multi-scale model framework for colonic stem cell homeostasis / Larry W. Jean and E. Georg Luebeck -- ch. 6. Multiscale modeling of colonic crypts and early colorectal cancer / Alexander G. Fletcher. [et al.] -- ch. 7. The physical microenvironment in somatic evolution of cancer / Robert A. Gatenby -- ch. 8. Multi-scale modeling of cell motion in three-dimensional environments / Dewi Harjanto and Muhammad H. Zaman -- ch. 9. Simulating cancer growth with agent-based models / Zhihui Wang. [et al.] -- ch. 10. Diffusional instability as a mechanism of tumor invasion / Hermann B. Frieboes, John Lowengrub, and Vittorio Cristini -- ch. 11. Continuum models of mesenchymal cell migration and sprouting angiogenesis / Michael Bergdorf, Florian Milde, and Petros Koumoutsakos -- ch. 12. Do tumor invasion strategies follow basic physical laws? / Caterina Guiot, Pier Poalo Delsanto, and Antonio S. Gliozzi -- ch. 13. Multiscale mathematical modeling of vascular tumor growth : an exercise in transatlantic cooperation / Mark A.J. Chaplain. [et al.] -- ch. 14. A multiscale simulation framework for modeling solid tumor growth with an explicit vessel network / Sven Hirsch. [et al.] -- ch. 15. Building stochastic models for cancer growth and treatment / Natalia L. Komarova -- ch. 16. Bridging from multiscale modeling to practical clinical applications in the study of human gliomas / Gargi Chakraborty. [et al.] -- ch. 17. Personalization of reaction-diffusion tumor growth models in MR images : application to brain gliomas characterization and radiotherapy planning / Ender Konukoglu. [et al.] -- ch. 18. In Silico oncology : part I, clinically oriented cancer multilevel modeling based on discrete event simulation / Georgios S. Stamatakos -- ch. 19. In silico oncology : part II, clinical requirements regarding In Silico oncology / Norbert Graf.