chapter 1 Bioanalytical Assays in a Drug Discovery Environment / chapter 2 Drug Metabolism In Vitro and In Vivo Results: How Do these Data Support Drug Discovery? / chapter 3 High Throughput Strategies for In Vitro ADME Assays: How Fast Can We Go? / chapter 4 Matrix Effects: Causes and Solutions / chapter 5 Direct Plasma Analysis Systems / chapter 6 Acyl Glucuronides: Assays and Issues / chapter 7 Utilizing Higher Mass Resolution in Quantitative Assays / chapter 8 Special Requirements for Metabolite Characterization / chapter 9 APPI: A New Ionization Source for LC and MS/MS / chapter 10 Q Trap MS: A New Tool for Metabolite Identification / chapter 11 MS Imaging: New Technology Provides New Opportunities / chapter 12 Understanding the Role and Potential of Infusion Nanoelectrospray Ionization for Pharmaceutical Bioanalysis