chapter 1 Chapter Analytical issues in combinatorial chemistry -- chapter 2 Chapter An examination of the analytical sample: resin support -- chapter 3 Chapter Solid-phase reaction optimization using FTIR -- chapter 4 Chapter Reaction optimization using MS and NMR methods -- chapter 5 Chapter Reaction optimization using spectrophotometric and other methods -- chapter 6 Chapter Quality control of combinatorial libraries -- chapter 7 Chapter High-throughput purification -- chapter 8 Chapter Final thoughts and future perspectives.