ch. 1. Functional groups in biopolymers and factors influencing reactivity -- ch. 2. Modification of amino/amidino groups in proteins -- ch. 3. Modification of hydroxyl and carboxyl functional groups in proteins -- ch. 4. Modification of heterocyclic amino acids : histidine and tryptophan -- ch. 5. Modification of sulfur-containing amino acids in proteins -- ch. 6. Chemical modification of nucleic acids -- ch. 7. Chemical modification of polysaccharides.