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Anticancer therapeutics : from drug discovery to clinical applications

Todd, Adam A., 1982- author.

Anticancer therapeutics : from drug discovery to clinical applications

Todd, Adam A., 1982- author.

9781118696217

9781118696194

9781118696200

First edition.

1 online resource

Intro -- Title Page -- Copyright Page -- Contents -- Preface -- Section 1 Introduction -- Chapter 1.1 The Global Burden of Cancer -- References -- Chapter 1.2 Cancer Staging and Classification -- 1.2.1 Benign Tumour (or neoplasm) -- 1.2.2 Malignant Tumour (or cancer) -- 1.2.3 Tumour Nomenclature and Classification -- 1.2.4 Cellular Differentiation and Tumour Grade -- 1.2.5 Tumour Invasion and Metastasis -- 1.2.6 Clinical Staging of Cancer -- References -- Chapter 1.3 Cellular and Molecular Basis of Cancer -- 1.3.1 Oncogenes -- 1.3.2 Tumour Suppressor Genes -- 1.3.3 Role of Epigenetics and Gene Promoter Regulation in Tumourigenesis -- 1.3.4 Multistage Tumourigenesis -- 1.3.5 Oncogene Addiction -- 1.3.6 Hallmarks of Cancer -- 1.3.7 Principles of Cancer Treatment -- References -- Section 2 The Anticancer Agents -- Chapter 2.1 Agents Which Act Directly on DNA -- 2.1.1 Nitrogen Mustards and Nitrosoureas -- References -- 2.1.2 Temozolomide -- References -- 2.1.3 Platinum-containing agents -- References -- 2.1.4 Gemcitabine -- References -- 2.1.5 Camptothecin and Its Analogues -- References -- 2.1.6 Podophyllotoxins -- References -- 2.1.7 Anthracyclines [1] -- References -- 2.1.8 Epigenetic Targeting Agents [1] -- References -- Chapter 2.2 Antimetabolites -- 2.2.1 Cytarabine -- References -- 2.2.2 Methotrexate -- References -- 2.2.3 5-Fluorouracil -- References -- 2.2.4 6-Mercaptopurine -- References -- Chapter 2.3 Antimicrotubule agents -- 2.3.1 Taxanes -- References -- 2.3.2 Vinca Alkaloids -- References -- Chapter 2.4 Anti-hormonal agents -- 2.4.1 Bicalutamide -- References -- 2.4.2 Tamoxifen -- References -- 2.4.3 Anastrozole [1] -- References -- Chapter 2.5 Kinase Inhibitors -- 2.5.1 Discovery -- 2.5.2 Synthesis -- 2.5.3 Mode of Action -- 2.5.4 Mechanism of Resistance [32] -- 2.5.5 Adverse Drug Reactions -- References -- Section 3 The Cancers.

Chapter 3.1 Breast Cancer -- 3.1.1 Epidemiology -- 3.1.2 Presentation -- 3.1.3 Diagnosis -- 3.1.4 Staging -- 3.1.5 Treatments -- References -- Chapter 3.2 Colorectal cancer -- 3.2.1 Epidemiology -- 3.2.2 Presentation -- 3.2.3 Diagnosis -- 3.2.4 Staging -- 3.2.5 Treatments -- References -- Chapter 3.3 Leukaemia -- 3.3.1 Epidemiology -- 3.3.2 Presentation -- 3.3.3 Diagnosis -- 3.3.4 Staging -- 3.3.5 Treatments -- References -- Chapter 3.4 Lung cancer -- 3.4.1 Epidemiology -- 3.4.2 Presentation -- 3.4.3 Diagnosis -- 3.4.4 Staging -- 3.4.5 Treatments -- References -- Chapter 3.5 Oesophageal Cancer -- 3.5.1 Epidemiology -- 3.5.2 Presentation -- 3.5.3 Diagnosis -- 3.5.4 Staging -- 3.5.5 Treatments -- References -- Chapter 3.6 Ovarian cancer -- Key points -- 3.6.1 Epidemiology -- 3.6.2 Presentation -- 3.6.3 Diagnosis -- 3.6.4 Staging -- 3.6.5 Treatments -- References -- Chapter 3.7 Pancreatic Cancer -- 3.7.1 Epidemiology -- 3.7.2 Presentation -- 3.7.3 Diagnosis -- 3.7.4 Staging -- 3.7.5 Treatments -- References -- Chapter 3.8 Prostate Cancer -- 3.8.1 Epidemiology -- 3.8.2 Presentation -- 3.8.3 Diagnosis -- 3.8.4 Staging -- 3.8.5 Treatments -- References -- Chapter 3.9 Skin Cancers -- 3.9.1 Epidemiology -- 3.9.2 Presentation -- 3.9.3 Diagnosis -- 3.9.4 Staging -- 3.9.5 Treatments -- References -- Chapter 3.10 Testicular cancer -- 3.10.1 Epidemiology -- 3.10.2 Presentation -- 3.10.3 Diagnosis -- 3.10.4 Staging -- 3.10.5 Treatments -- References -- Index -- EULA.

An integrated presentation of the basic science and clinical applications of anticancer agents Aimed at both undergraduate and postgraduate readers, this unique text provides readers with a fully-integrated presentation of all aspects of the science of anticancer drugs, including their chemistry, pharmacology, and clinical applications. After heart disease, cancer is the number one killer worldwide, and the tumor microenvironment is forever changing, creating an ever-greater demand for safer, more effective anticancer agents. In response to that demand, the $100 billion cancer drug market continues to grow, with our increased understanding of cancer leading to new drugs being used clinically almost every year. Anticancer Therapeutics is divided into three sections. Section 1 is an introduction to cancer and therapeutics, and covers the etiology and cellular and molecular basis of cancer. In Section 2, the authors focus on the anticancer agents-their discovery, synthesis, mode of action, mechanisms of resistance, and adverse reactions. Section 3 focuses on specific cancers, explaining how and why the various agents discussed in Section 2 are used, both individually and in combination, to treat different cancers.-Integrates aspects of basic science, including chemistry and pharmacology and clinical medicine in relation to cancer therapeutics -Written by an author team comprising specialists in medicinal chemistry, pharmacology, and oncology -Features full-color images throughout illustrating how drugs bind to cellular targets and exert their pharmacological effect -Divided into three sections, covering the etiology and cellular and molecular basis of cancer, anticancer agents, and drug applications for different cancers. Providing the reader with an integrated understanding of all aspects of the science of anticancer agents, this is an ideal textbook for undergraduates studying medicine, nursing, medicinal chemistry, pharmacy, pharmacology and other allied heath / life sciences. It is also a valuable bench reference for pharmacists, medics, and pharmaceutical researchers working in both academia and industry.

John Wiley and Sons

Antineoplastic agents -- Development.

Antineoplastic agents -- Design.

Antineoplastic agents -- Therapeutic use.

Antimitotic agents.

Antineoplastic agents.

Neoplasms -- drug therapy

Neoplasms -- physiopathology

Antineoplastic Agents

Drug Discovery

Antimitotic Agents

Anticancéreux -- Emploi en thérapeutique.

Anticancéreux.

SCIENCE -- Chemistry -- Industrial & Technical.

Industrial & Technical.

Chemistry.

SCIENCE.

Antineoplastic agents -- Design

Antineoplastic agents -- Development

Antineoplastic agents -- Therapeutic use

Electronic books.

Internet Resources.

Groundwater, Paul W.,

Gill, Jason, 1973-

https://onlinelibrary.wiley.com/doi/book/10.1002/9781118696194