Overview: clinical fundamentals of hepatology. History taking and physical examination for the patient with liver disease / Esperance A Schaefer, Lawrence S Friedman -- Laboratory tests, noninvasive markers of fibrosis, liver biopsy, and laparoscopy / Michael P Curry, Lennox J Jeffers -- Noninvasive and invasive imaging of the liver and biliary tract / Koushik K Das, Matthew A Morgan, Gregory G Ginsberg -- General considerations. Physioanatomic considerations / Ian R Wanless -- Bilirubin metabolism and jaundice / Allan W Wolkoff, Paul D Berk -- Hepatic histopathology / Zachary D Goodman -- Mechanisms of liver injury / Harmeet Malhi, Gregory J Gores -- Hepatic manifestations of systemic disorders / Stuart C Gordon, Humberto C Gonzalez -- The liver in pregnancy / Nancy Reau, Yannick Bacq -- Consequences of liver disease. Hepatic fibrosis / Scott L Friedman -- Preoperative evaluation of the patient with liver disease / Patrick S Kamath, Mark T Keegan -- Management of portal hypertension / Guadalupe Garcia-Tsao, Juan G Abraldes -- Renal complications of liver disease and the hepatorenal syndrome / Xingxing S Cheng, W Ray Kim -- Pulmonary manifestations of liver disease / Michael B Fallon, Anil Seetharam -- Ascites and spontaneous bacterial peritonitis / Vicente Arroyo, Javier Fernández -- Hepatic encephalopathy / Chathur Acharya, Jasmohan S Bajaj -- Acute liver failure / Robert J Fontana, Khurram Bari -- Acute-on-chronic liver failure / Florence Wong -- Malnutrition and liver disease / Craig McClain, Irina Kirpich, Laura Smart -- Cholestatic disorders. Primary sclerosing cholangitis / John M Vierling -- Primary biliary cholangitis / Cynthia Levy, Andres F Carrion, Marlyn J Mayo -- Autoimmune hepatitis / Gideon M Hirschfield, Gwilym J Webb -- Viral hepatitis. Hepatitis a and e / Kenneth E Sherman, Shyam Kottilil -- Hepatitis b and d / Marc G Ghany, Naveen Gara -- Hepatitis c / Michael W Fried, Jama M Darling, Stanley M Lemon -- Alcohol- and drug-induced liver disease. Alcoholic liver disease / Mack C Mitchell, Gyongyi Szabo -- Drug-induced hepatotoxicity / Dominique Larrey, Jose Ursic-Bedoya, Lucy Meunier -- Mechanisms of drug-induced liver injury / Paul B Watkins, Merrie Mosedale -- Genetic and metabolic disease. Wilson disease / Michael L Schilsky, Aftab Ala -- Hemochromatosis and iron storage disorders / Kris V Kowdley, Priya Handa -- Alpha-1 antitrypsin deficiency / David H Perlmutter -- Nonalcoholic fatty liver disease / Curtis K Argo, Zachary H Henry, Stephen H Caldwell -- Vascular diseases of the liver. Vascular liver disease / Dominique-Charles Valla -- The liver in circulatory failure / Santiago J Munoz, Hanisha R Manickavasagan, Idean Amirjazil -- Benign and malignant tumors; cystic disorders. Benign tumors, nodules, and cystic diseases of the liver / Julien Calderaro, Jessica Zucman-Rossi -- Hepatocellular carcinoma / Maddie Kubiliun, Jorge A Marrero -- Surgical options in liver cancers / Garrett R Roll, John Paul Roberts -- Infectious and granulomatous disease. Amoebic and pyogenic liver abscesses / Marco A Olivera-Martínez, David Kershenobich -- Parasitic diseases / Michael A Dunn -- Granulomas of the liver / James H Lewis -- Elements of liver transplantation. Selection of candidates and timing of liver transplantation / Meaghan Phipps, Alyson N Fox, Robert S Brown -- Immunosuppression: the global picture / Caroline C Jadlowiec, Timucin Taner, Russell H Wiesner -- The first six months following liver transplantation / K Rajender Reddy, Manuel Mendizabal -- Long-term management of the liver transplant patient / Timothy M McCashland -- The liver transplant procedure / Bijan Eghtesad, Koji Hashimoto, John Fung -- Recurrent disease following liver transplantation / Haripriya Maddur, Josh Levitsky -- The role of retransplantation / Peter L Abt, Kim M Olthoff -- Controversies in liver transplantation / James F Trotter.