Intro; Evidence-Based Gastroenterology and Hepatology; Dedication; Contents; Contributors; Preface; PART I Gastrointestinal disorders; 1 Gastroesophageal reflux disease; Introduction; Definition of GERD; Clinical presentation; Epidemiology; Pathophysiology; Natural history and complications; Diagnostic tests; Symptom assessment and questionnaires; PPI trial; Upper GI endoscopy; Ambulatory GERD testing: pH and pH-impedance monitoring; Esophageal high-resolution manometry; Barium swallow; Mucosal impedance; Treatment; Lifestyle modifications; Antacids and alginates

Histamine-2 receptor antagonistsProton pump inhibitors; Potassium competitive acid blockers; Reflux inhibitors; Prokinetic drugs; Targeting hypersensitivity; Antireflux surgery; Novel surgical and endoscopic procedures; Conclusion; References; 2 Barretts esophagus; Introduction; Definition; Pathogenesis; Epidemiology; Incidence and prevalence; Risk factors; Natural history; Diagnosis; Endoscopy; Diagnosis-histopathology; Advanced endoscopic imaging in BE; Screening and surveillance; Screening; Surveillance; Treatment; Acid suppression

Chemoprevention of esophageal adenocarcinoma with anti-inflammatory agentsEndoscopic therapies for Barretts esophagus; Conclusion; References; 3 Esophageal motility disorders; Achalasia; Treatment of achalasia; Overview; Pharmacologic treatment; Botulinum toxin; Pneumatic dilation; Heller myotomy; Per-oral endoscopic myotomy (POEM); Comparisons among treatment modalities; Esophagectomy; Summary; Spastic motor disorders; Treatment of spastic motility disorders; Overview; Medications; Botulinum toxin; Pneumatic dilation; Heller myotomy; POEM; Summary; References; 4 Eosinophilic esophagitis

IntroductionSearching for the evidence; Definition; Etiology and pathogenesis; Genetics and genetic variants; Environmental factors; Epidemiology; Diagnosis; General approach and differential diagnosis; GERD and PPI-REE; Features in children; Features in adults; Endoscopic features; Histologic features; Prognosis and natural history; Management; Corticosteroids; Biologics; Leukotriene antagonists and mast cell stabilizers; Immunomodulators; Dietary therapy; Endoscopic management with dilation; Future advances; Evaluation and prognosis; Novel therapies; Summary of treatment data

AcknowledgmentsReferences; 5 Ulcer disease and Helicobacter pylori infection: current treatment; Introduction; What is the evidence for the role of H. pylori in peptic ulcer disease?; Association of H. pylori with ulcer disease (strength, consistency, and specificity); Duodenal ulcer; Duodenal ulcers not related to H. pylori and NSAIDs; Gastric ulcer; Temporal relationship; Biological gradient; Biological plausibility; Effects of interventions: outcomes following H. pylori eradication; Coherence of the data with earlier epidemiological information; Treatment of duodenal ulcer