Front Matter -- Systematic Reviews in Health Research / Matthias Egger, Julian PT Higgins, George Davey Smith -- PRINCIPLES AND PROCEDURES. Principles of Systematic Reviewing / Julian PT Higgins, George Davey Smith, Douglas G Altman, Matthias Egger -- Identifying Randomized Controlled Trials / Julie Glanville, Carol Lefebvre -- Assessing the Risk of Bias in Randomized Trials / Matthew J Page, Douglas G Altman, Matthias Egger -- Investigating and Dealing with Publication Bias and Other Reporting Biases / Matthew J Page, Jonathan AC Sterne, Julian PT Higgins, Matthias Egger -- Managing People and Data / Eliane Rohner, Julia Bohlius, Bruno R Costa, Sven Trelle -- Reporting and Appraisal of Systematic Reviews / Larissa Shamseer, Beverley Shea, Brian Hutton, David Moher -- META-ANALYSIS. Effect Measures / Julian PT Higgins, Jonathan J Deeks, Douglas G Altman -- Combining Results Using Meta-Analysis / Jonathan J Deeks, Richard D Riley, Julian PT Higgins -- Exploring Heterogeneity / Julian PT Higgins, Tianjing Li -- Dealing with Missing Outcome Data in Meta-Analysis / Ian R White, Dimitris Mavridis -- Individual Participant Data Meta-Analysis / Mark C Simmonds, Lesley A Stewart -- Network Meta-Analysis / Georgia Salanti, Julian PT Higgins -- Dose-Response Meta-Analysis / Nicola Orsini, Susanna C Larsson, Georgia Salanti -- SPECIFIC STUDY DESIGNS. Systematic Reviews of Nonrandomized Studies of Interventions / Jelena Savović, Penny F Whiting, Olaf M Dekkers -- Systematic Reviews of Diagnostic Accuracy / Yemisi Takwoingi, Jonathan J Deeks -- Systematic Reviews of Prognostic Factor Studies / Richard D Riley, Karel GM Moons, Douglas G Altman, Gary S Collins, Thomas PA Debray -- Systematic Reviews of Prediction Models / Gary S Collins, Karel GM Moons, Thomas PA Debray, Douglas G Altman, Richard D Riley -- Systematic Reviews of Epidemiological Studies of Etiology and Prevalence / Matthias Egger, Diana Buitrago-Garcia, George Davey Smith -- Meta-Analysis in Genetic Association Studies / Gibran Hemani -- COCHRANE AND GUIDELINE DEVELOPMENT. Cochrane / Gerd Antes, David Tovey, Nancy Owens -- Using Systematic Reviews in Guideline Development / Holger J Schünemann -- OUTLOOK. Innovations in Systematic Review Production / Julian Elliott, Tari Turner -- Future for Systematic Reviews and Meta-Analysis / Shah Ebrahim, Mark D Huffman -- SOFTWARE. Meta-Analysis in Stata / David J Fisher, Marcel Zwahlen, Matthias Egger, Julian PT Higgins -- Meta-Analysis in R / Guido Schwarzer -- Comprehensive Meta-Analysis Software / Michael Borenstein -- Index