Current Drug Discovery / Jeffrey J Hale -- Advanced Computational Modeling Accelerating Small-Molecule Drug Discovery / Robert Abel -- Discovery and Development of the Soluble Guanylate Cyclase Stimulator Vericiguat for the Treatment of Chronic Heart Failure / Markus Follmann, Corina Becker, Lothar Roessig, Peter Sandner, Johannes-Peter Stasch -- Finding Cures for Alzheimer's Disease / Xianhai Huang, Robert Aslanian -- Discovery of Novel Antiviral Agents Enabled by Structural Biology, Compact Modules and Phenotypic Screening / Wei Zhu, Song Yang, Hongying Yun, Hong C Shen -- Discovery of Subtype Selective Agonists of the Group II Metabotropic Glutamate Receptors / Junliang Hao -- Discovery of Taselisib (GDC-0032) / Timothy P Heffron, Laurent Salphati, Steven T Staben -- Drug Discovery with DNA-Encoded Library Technology / Yun Ding, Sarah K Scott -- Discovery of HTL26119 / Andrea Bortolato, Jonathan S Mason -- Discovery and Potential Application of [11C]MK-6884 / Ling Tong, Wenping Li -- Targeted Protein Degradation by Proteolysis Targeting Chimeras / Wu Du -- Entrepreneurial Drug Hunter / Tomi Sawyer -- Application of Pyrrolobenzodiazepines in Antibody Drug Conjugates / Ning Zou, Amy Han -- Combination Therapy Case Studies in Anticancer and Anti-Infectious Disease Drug Discovery and Development / Xianhai Huang, David Yu-Kai Chen -- Accelerating Drug Discovery and Development / Xianhai Huang, David Yu-Kai Chen, Wayne Haifeng Tang -- Appendix A: Monoclonal Antibody Drug Discovery and Development Paradigm -- Appendix B: Glossary -- Appendix C: Abbreviations.