Flow and microreactor technology in medicinal chemistry
by
 
Alza, Esther, editor.

Title
Flow and microreactor technology in medicinal chemistry

Author
Alza, Esther, editor.

ISBN
9783527824595
 
9783527824618

Physical Description
1 online resource.

Series
Methods and principles in medicinal chemistry ; volume 81
 
Methods and principles in medicinal chemistry ; v. 81.

General Note
Includes index.

Contents
Front Matter -- Flow Chemistry at the Extremes: Turning Complex Reactions into Scalable Processes / Andrew R Bogdan -- Automated Flow Chemistry Platforms / Juan A Rincón, María José Nieves-Remacha, Carlos Mateos -- Flow Chemistry Opportunities for Drug Discovery / María Lourdes Linares, Enol López, Eduardo Palao, Jesús Alcázar -- Flow Chemistry in Medicinal Chemistry: Applications to Bcr - Abl Kinase Inhibitors / Paul Richardson -- Integrated Systems for Continuous Synthesis and Biological Screenings / Antimo Gioiello, Giada Moroni, Bruno Cerra -- Application of Continuous-Flow Processing in Multistep API and Drug Syntheses / Faith M Akwi, Paul Watts -- Continuous-Flow Multistep Synthesis of Active Pharmaceutical Ingredients / Yuesu Chen, Jean-Christophe M Monbaliu -- Enantioselective (Bio)Catalysis in Continuous-flow as Efficient Tool for the Synthesis of Advanced Intermediates and Active Pharmaceutical Ingredients / Laura Amenós, Anna M Sobolewska, Esther Alza, Miquel A Pericàs -- Innovative Process Development of Pharmaceutical Intermediates Under Continuous-Flow System / Koji Machida, Hiroaki Yasukouchi -- Index

Abstract
Learn to master a powerful technology to enable a faster drug discovery workflow The ultimate dream for medicinal chemists is the ability to synthesize new drug-like compounds with the push of a button. The key to synthesizing chemical compounds more quickly and accurately lies in computer-controlled technologies that can be optimized by machine learning. Recent developments in computer-controlled automated syntheses that rely on miniature flow reactors--with integrated analysis of the resulting products--provide a workable technology for synthesizing new chemical substances very quickly and with minimal effort. In Flow and Microreactor Technology in Medicinal Chemistry, early adopters of this ground-breaking technology describe its current and potential uses in medicinal chemistry. Based on successful examples of the use of flow and microreactor synthesis for drug-like compounds, the book introduces current as well as emerging uses for automated synthesis in a drug discovery context. Flow and Microreactor Technology in Medicinal Chemistry readers will also find: Numerous case studies that address the most common applications of this technology in the day-to-day work of medicinal chemists How to integrate flow synthesis with drug discovery How to perform enantioselective reactions under continuous flow conditions Flow and Microreactor Technology in Medicinal Chemistry is a valuable practical reference for medicinal chemists, organic chemists, and natural products chemists, whether they are working in academia or in the pharmaceutical industry.

Local Note
John Wiley and Sons

Subject Term
Pharmaceutical chemistry.
 
Microreactors.
 
Drug development.
 
Chemistry, Pharmaceutical
 
Chimie pharmaceutique.
 
Microréacteurs chimiques.
 
Médicaments -- Développement.
 
Industrial & Technical.
 
Chemistry.
 
SCIENCE.
 
Drug development
 
Microreactors
 
Pharmaceutical chemistry

Genre
Electronic books.

Added Author
Alza, Esther,

Electronic Access
https://onlinelibrary.wiley.com/doi/book/10.1002/9783527824595


LibraryMaterial TypeItem BarcodeShelf Number[[missing key: search.ChildField.HOLDING]]Status
Online LibraryE-Book597649-1001RS403Wiley E-Kitap Koleksiyonu