Targeted Protein Degradation - The Story So Far / Daniel H O Donovan, Laura M Luh, Philipp M Cromm -- Cellular Principles of Targeted Protein Degradation / João Diamantino, Doris Hellerschmied -- E3 Ubiquitin Ligases as Molecular Machines and Platforms for Drug Development / Rafael M Ioris, Katherine Ferris, Vincenzo D'Angiolella -- A Structural and Biophysical Perspective of Degrader Activity Through Ternary Complex Formation / Morgan S Gadd, Marine C Aublette -- Computational Modeling of PROTAC Ternary Complexes and Linker Design / Sven A Miller, Grigorii V Andrianov, Victoria Mischley, Khadija A Wharton, Jesse J Chen, John Karanicolas -- Molecular Glue Degraders: From Serendipity to Hunting and Design / Luis Nieto-Barrado, Ana Domostegui, Cristina Mayor-Ruiz -- Targeted Protein Degradation as a Therapeutic Strategy in Neurodegenerative Diseases / Fleur M Ferguson -- Insights and Future Perspectives of Covalent Protein Degraders / Xiaoyu Zhang -- Extending the Degradation Toolkit - mRNA Targeting as an Alternative Means to Affect Protein Levels / Andrei Ursu, Barbara Herdy, Hendrik Osadnik -- The Future of Heterobifunctional Compounds: PROTACs and Beyond / George M Burslem -- Destruction with a Purpose: Targeted Protein Degradation in Drug Discovery / Paola Martinelli, Christiane Kofink, Georg Boeck, Harald Weinstabl, Manfred Koegl -- Taming the Beast: How to Optimize DMPK-PD Properties of Oral Degraders / Caroline Rynn, Arthur Van De Vyver, Antje Walz, Carina Cantrill, Matthias Wittwer -- PROTAC ® Protein Degraders: Bridging the Divide from Chemical Biology Tools to Clinical Candidates / Erika MV Araujo, Keith R Hornberger.