This volume LNAI 16099 constitutes the refereed proceedings of the 19th European Conference on Symbolic and Quantitative Approaches to Reasoning with Uncertainty, ECSQARU 2025, held in Hagen, Germany, during September 23-26, 2025. The 34 full papers presented in this volume were carefully reviewed and selected from 48 submissions. The papers are organized in the following topical sections: Bayesian Networks; Learning and Probability; Game Theory and Social Choice; Conditionals, Inference, Change; Argumentation; Logic and Inconsistency.