1. Management of a PET site, the ability to reach great results through a small organization -- 1.1. Differences between the management of the production of SPECT and PET radiopharmaceuticals -- 1.2. An Italian Technician in Europe and in the World: what of our way of managing the production of radiopharmaceuticals can be an excellence? When the imagination can be an advantage -- 1.3. Commercial PET, "the spider out of the hole" -- 1.4. A good practice on communication to customer -- 2. PET third party collaborations -- 2.1 Development of a new tracer: connection between Research & Development (R&D) and industrial production -- 2.2. The selection of a new PET radiotracer -- 2.3. Three different manufacturing contracts with the CMO: for mature, new, investigational tracers -- 2.4. Customer order management: CMO or Corporate responsibility? -- 2.5. Collaborations with non-industrial entities (hospitals or research centers). Two different mindsets, how to reconcile them? -- 2.6. Monitoring of production and distribution reliability in a PET network -- 3. Elements to take into account for an EU PET company acquisition -- 4. An old laboratory, in the cyclotron building front lake, and its strange inhabitants -- 5. A Sustainable PET Quality Assurance (QA) -- 5.1. The reasons for a choice: why working in Quality Assurance? -- 5.2. QA team of a PET site: how to do a selection for the recruitment of operational and managerial personnel -- 5.3. PET site network: skills development, relationship with management, performance monitoring -- 5.4. Organization of the QA system in a PET Pharmaceutical Facility -- 5.5. Movie or reality? -- 6. The PET manufacturing experience in a public department, a witness -- 6.1. Reasons of a decision: developing a PET radiopharmacy for internal use in a public structure -- 6.2. From a research lab (or a clinical internal service) to an industrial set up -- 6.3. From words to deeds -- 6.4. Now that you got the horse, ride it -- Conclusions -- Final Greeting -- Glossary.-Recommended readings.