Peptide science : chemical ligation, lead generation, and therapeutic advances

Title:

Author:

Liu, Fa, editor.

ISBN:

9781119824688

9781119824695

9781119824701

Physical Description:

1 online resource : color illustrations

Contents:

Cover -- Half Title Page -- Title Page -- Copyright -- Contents -- List of contributors -- Preface -- Section I: New Developments in Peptide Chemistry -- 1: Chemical Peptide Ligations -- 1.1 Introduction -- 1.2 Ligation Driven by Trans-esterification -- 1.2.1 Native Chemical Ligation -- 1.2.1.1 Desulfurization -- 1.2.1.2 Auxiliary-assisted NCL -- 1.2.1.3 Backbone-installed Split Intein-assisted Ligation -- 1.2.2 Diselenide/Selenoester Ligation -- 1.3 Ligation Driven by Imine Capture -- 1.3.1 Serine/Threonine Ligation -- 1.3.2 Cysteine/Penicillamine Ligation

1.4 Ligation Initiated by Hydroxylamine -- 1.5 Ligation in Protein Synthesis -- 1.5.1 Sequential Ligation and Chemical Protein Synthesis -- 1.5.1.1 Terminal Latent and Activation -- 1.5.1.2 Ligation Intermediates Facilitate Difficult Peptide Synthesis -- 1.5.1.3 Chemical Protein Synthesis -- 1.5.2 Protein Semi-synthesis -- 1.6 Ligations in Drug Development -- 1.6.1 Ligation in Macrocyclic Peptide Synthesis -- 1.6.2 Mirror-image Phage Display -- 1.7 Summary and Outlook -- 2 Protein and Peptide Ligation Using Peptide Ligases -- 2.1 Introduction -- 2.2 Peptide Ligases Mechanism of Action

2.3 Sortase -- 2.4 Peptide Asparaginyl Ligases -- 2.5 Subtilisin-derived Peptide Ligases -- 2.6 Trypsiligase -- 2.7 Conclusion -- 3: Modern Methods for Late-stage Peptide Modification -- 3.1 Introduction -- 3.2 Methionine -- 3.3 Aspartate and Glutamate -- 3.4 Arginine -- 3.5 Tryptophan -- 3.6 Functionalization of sp2 C-H Bonds: Tyr, Phe, and His -- 3.6.1 Tyrosine -- 3.6.2 Phenylalanine -- 3.6.3 Histidine -- 3.7 Functionalization of sp3 C-H Bonds -- 3.8 Other X-H Functionalizations -- 3.9 Conclusion -- Section II: Peptide Drug Hit Identification

4: Generating Phage Libraries Bearing Unnatural Pharmacophores -- 4.1 Introduction -- 4.2 Biotin Capture Assay to Detect Chemical Modification of Phage Libraries -- 4.3 N-terminal Oxidation and Functionalization to Incorporate Unnatural Fragments -- 4.4 Macrocyclization of Phage-displayed Peptides Bearing Cysteines -- 4.5 Macrocyclization and Installation of Warheads in Phage-displayed Libraries -- 4.6 Outlook -- 5: Computational Peptide Design for Diverse Structures and Functions -- 5.1 The Various Types of Peptides -- 5.2 In Silico Peptide Design: From Physics-based Methods to DL

5.3 Physics-based Methods -- 5.3.1 Motif-based Design with Physics-based Methods -- 5.3.2 De Novo Design with Physics-based Methods -- 5.3.2.1 Peptide Design with Rosetta Generalized Kinematic Closure -- 5.3.2.2 De Novo Peptide Binder Design with Physics-based Methods -- 5.3.2.3 Molecular Dynamics-based Peptide Design -- 5.4 DL Methods for Peptide Design -- 5.4.1 Structure-based DL Methods for Peptide Design -- 5.4.2 PLMs for Peptide Design -- 5.5 Optimizing for Membrane Permeability and Stability -- 5.6 Remaining Challenges -- 5.7 Conclusion

Abstract:

Understand the nature and applications of peptides with this clear and comprehensive guide Peptides are signaling molecules comprised of amino acids which play an important role in modulating certain physiological processes. They have a wide range of applications, particularly with respect to biological studies and therapeutical potentials. The explosive growth of peptide science in recent years and the variety of achievements in peptide drug discovery and related areas have made it an important area of study for new researchers and industry professionals. Peptide Science offers a clear, systematic overview of this burgeoning field and its major applications. Covering the chemistry, the pertinent technologies, and major existing therapies, it provides the tools required to integrate peptide research with virtually any area of research and development. Fully cognizant of the latest technological advances, it's a must-own for anyone looking to understand a vital field of chemistry. Peptide Science readers will also find: Through coverage of peptide hit generation technologies from nature, to various display libraries and to modern computational designs Detailed discussion of therapies for conditions including cancer, diabetes, infectious diseases, and more A section dedicated to key challenges and future directions in peptide therapeutics Peptide Science is ideal for industry professionals and researchers in organic chemistry, peptide science/chemistry, protein chemistry, biochemistry, and pharmaceutical sciences.

Local Note:

John Wiley and Sons

Subject Term:

Peptides -- Therapeutic use.

Peptides -- Synthesis.

Peptide drugs.

Drug development.

Peptides -- Emploi en thérapeutique.

Peptides -- Synthèse.

Médicaments peptidiques.

Médicaments -- Développement.

Pharmacology.