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Cover image for New drug development for known and emerging viruses
Title:
New drug development for known and emerging viruses
Author:
Rübsamen-Schaeff, Helga, editor.
ISBN:
9783527810697
Physical Description:
1 online resource.
Series:
Methods and principles in medicinal chemistry

Methods and principles in medicinal chemistry.
Contents:
Disease Overview, Targets for Therapy and Open Issues / Christoph Stephan -- Curing Hepatitis C with Direct-Acting Antiviral Therapy / Michael J Sofia -- Antiviral Drugs Against Influenza Virus / Oliver Planz -- Respiratory Syncytial Virus Immunoreactivity, Vaccine Development, and Therapeutics / Farah Elawar, Matthias Gotte, Nelson Lee, Rachel Fearns, David J Marchant -- Herpes Simplex Viruses / Alexander Birkmann -- Antiviral Strategies Against the Human Cytomegalo Virus / Helga Rübsamen-Schaeff -- Antiviral Targeting of the Complex Epstein Barr Virus Life Cycle / Christian Münz -- Kaposi's Sarcoma-associated Herpesvirus-Antiviral Treatment / Thomas F Schulz -- Direct-Acting Antivirals for the Treatment of Chronic Hepatitis B Virus (HBV) Infection / Angelica Corcuera, Alastair Donald, Andreas Urban -- Hepatitis E Virus-Current Developments in Antiviral Strategies / Daniel Todt, Patrick Behrendt, Eike Steinmann -- Antiviral Therapy of Adenovirus Infections / Peter Lischka -- ssDNA-Viruses: Human Parvovirus Infection / Susanne Modrow -- Antiviral Targets and Strategies to Treat and Prevent Human Norovirus Infections / Jana Van Dycke, Arno Cuvry, Johan Neyts, Joana Rocha-Pereira -- Antiviral Strategies Against (Non-polio) Picornaviruses / Rana Abdelnabi, Jim Baggen, Carmen Mirabelli, Johan Neyts -- Novel Antiviral Strategies Against Emerging Arbovirus Infections / Yannick Brüggemann, Carina Elsner, Stephanie Pfaender -- Current Therapies for Biosafety Level 4 Pathogens / Lucie Fénéant*, Bianca Bodmer*, Thomas C Mettenleiter, Allison Groseth, Thomas Hoenen -- A Focus on Severe Acute Respiratory Syndrome (SARS) Coronavirus (SARS-CoVs) 1 and 2 / Rolando Cannalire, Enzo Tramontano, Vincenzo Summa.
Abstract:
Discusses how to fight Ebola, SARS Corona, and other known or emerging human viruses by building on the successes in antiviral therapy of the past decades Written by leading medicinal chemists from academia and industry, this book discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets, and viral disease mechanisms. It provides an outlook on emerging pathogens such as Ebola, Zika, West Nile, Lassa, and includes a chapter on SARS Coronoavirus-2 causing the present pandemic. New Drug Development for Known and Emerging Viruses describes the discovery and development process for antiviral agents for different classes of viruses and targets based on the experiences from the nine human viruses for which approved drugs are on the market (HIV, HCV, Influenza, RSV, HBV, HPV, HCMV, HSV, and VZV). It covers the properties and potential of 20 classes of currently approved antivirals, including combination drugs, and looks at novel antiviral strategies against emerging viruses. * Covers the entire field of antiviral drug discovery and development * Addresses the need for antiviral drugs to combat major health threats such as Ebola, Zika, West Nile, and SARS Coronavirus-2 * Summarizes the successes of the past 15 years in developing ground-breaking medicines against 9 major human viruses, both from the medicinal chemistry and the pharmacological angle * Discusses practical and strategic challenges in the drug discovery and development process, including screening technologies, latency, and toxicity issues New Developments in Antiviral Drugs is an important book for medicinal chemists, pharmaceutical chemists, virologists, and epidemiologists, and will be of great interest to those in the;pharmaceutical industry and public health agencies.
Local Note:
John Wiley and Sons
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E-Book 597274-1001 RM411 .N49 2022
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