Animal models for the development of cancer immunotherapy

Title:

Author:

Tan, Seng-Lai, editor.

ISBN:

9781119535331

9781119535317

9781119535270

Physical Description:

1 online resource

Contents:

Transplantable Syngeneic Tumor Models / Richard Woessner, Simon Dovedi, Robert Wilkinson -- Genetically Engineered Mouse Models (GEMM) in Cancer Immunotherapy R&D / Zhao Chen -- Mouse Tumor Homografts Recapitulate Human Molecular Pathogenesis / Rajendra Kumari, Davy Ouyang, Henry Li. -- Modeling Resistance to Immune Checkpoint Blockade / Michael Quigley, Matthew J. Meyer and Kanstantsin Katlinski -- Orthotopic Mouse Models of Colorectal Cancer and Imaging Techniques / Ce Yuan, Xianda Zhao, Dechen Wangmo, Duha Alshareef, Subbaya Subramanian -- Preclinical Osteoimmuno-oncology Models to Study Effects of Immunotherapies on Bone Metastasis / Tiina E. Kähkönen, Jussi M. Halleen, Jenni Bernoulli -- Humanized mouse models for cancer immunotherapy : a focus on human PBMC and HSPC reconstitution / Zhuo Li, Xiao Yang, Xiaomin Song -- Bone Marrow-Liver-Thymus (BLT) Humanized Mice as a Tool to Assess Checkpoint Inhibitor Adverse Events / Kenrick M. Semple, Alan D. Knapton and Kristina E. Howard -- Development of Swine Models for Cancer Research : SCID Pigs and Other Emerging Pig Models / Adeline N Boettcher and Christopher K Tuggle.

Abstract:

"There has been an explosion of preclinical and clinical research leading to FDA approvals of immunotherapies that harness or enhance a patient's immune system to target tumors. However, despite promising clinical results, checkpoint blockade therapies can show intrinsic and acquired resistance and only certain tumor types respond more favorably than others. Animal models are valuable tools for studying these issues and for the preclinical evaluation of immune modulators"-- Provided by publisher.

Local Note:

John Wiley and Sons

Subject Term:

Tumors -- Treatment.

Diseases -- Animal models.

Neoplasms -- therapy

Immunotherapy -- methods

Disease Models, Animal

Tumeurs -- Traitement.

Maladies -- Modèles animaux.

Pharmacology.

Immunology.