Human and animal filariases : landscape, challenges, and control

Title:

Author:

Kaminsky, Ronald, editor.

ISBN:

9783527823413

9783527823437

9783527823420

Physical Description:

1 online resource.

Series:

Drug Discovery in Infectious Diseases Ser.

General Note:

Includes index.

Contents:

Human and Animal Filariae and Their Diseases. Breaking the Silos - Obstacles and Opportunities for One Health in Filariases / Ronald Kaminsky, Timothy G Geary -- Filariae as Organisms / Pascal Mäser -- Human Filarial Infections: Reflections on the Current Understanding of Their Importance, Pathobiology, and Management / Charles D Mackenzie -- Canine Filariasis (Heartworm) - Disease and Current Gaps / Dwight D Bowman*, Timothy K Wu -- Diagnosis and Assessment of Human Filarial Infections: Current Status and Challenges / Charles D Mackenzie, Ashley Souza, Timothy G Geary -- Veterinary Diagnosis of Filarial Infection / Christopher Evans, Nils Pilotte, Steven Williams, Andrew Moorhead -- Antifilarial Chemotherapy: Current Options for Humans / Sabine Specht, Joseph Kamgno, Timothy G Geary -- Antifilarial Chemotherapy: Current Options in Veterinary Medicine / Jennifer Ketzis, Christian Epe -- Heartworm Disease - Intervention and Industry Perspective 1 / Sandra Noack, John Harrington, Douglas S Carithers, Ronald Kaminsky, Paul M Selzer -- Current Antifilarial Drugs - Mechanisms of Action / Timothy G Geary, Alan Long, Lucienne Tritten -- Drug Resistance in Filariae / Roger Prichard -- Elimination and Eradication of Human Filariases / Boakye A Boatin, Frank O Richards Jr, Kapa D Ramaiah, John O Gyapong -- Drug Discovery for Novel Antifilarials. Global Economics of Heartworm Disease / Darrell Klug, Jason Drake -- Product Profiles for New Drugs Against Human and Animal Filariasis / Sabine Specht, Ronald Kaminsky -- Discovery and Development of New Antifilarial Drugs (In Vitro Assays) / Lucien Rufener, Alexandre Vernudachi, Ronald Kaminsky, Thomas Duguet -- In Vivo Models for the Discovery of New Antifilarial Drugs / Sandra Schorderet-Weber, Sabine Specht -- In Vivo Assays - Discovery and Development of New Antifilarial Drugs in Companion Animals / Heinz Sager, Regina Lizundia, William H White -- The Antifilarial Drug Pipeline / Natalie A Hawryluk* -- New Frontiers for Control of Antifilarial Diseases. The Host-Helminth Interface as a Rich Resource for Novel Drug Targets / Thomas B Duguet, Lucienne Tritten -- Functional Genomics of Filariae / Eileen Devaney, Collette Britton -- Development of a Vaccine Against Onchocerca volvulus / David Abraham, Ben Makepeace, Sara Lustigman -- Vector Control Approaches to Interrupt Transmission of Human Filarial Parasites / Lyric Bartholomay* -- Vector Control Approaches for Canine Filariasis / Sofija Todorovic, Tanja McKay, Phillip Kaufman -- Wolbachia Endosymbionts as Treatment Targets for Filarial Diseases / Marc P Hübner, Kenneth Pfarr, Achim Hoerauf.

Abstract:

Filariae are a family of parasitic worms which infect animals and humans, causing severe diseases such as elephantiasis (lymphatic filariasis) and river blindness (onchocerciasis) in humans, as well as heartworm disease (dirofilariasis) in dogs and cats. While the human diseases are rarely fatal, the blindness and disfiguration resulting from these infections constitute a severe burden for the affected individuals and to the healthcare systems in many tropical countries. In 2017, the World Health Organization classified several filariases as neglected tropical diseases and announced a new program seeking to eradicate these infections, which has in turn sparked a new push to develop antifilarial drugs. Considering the current and future import of this topic, Human and Animal Filariases takes a comprehensive look at infections by filarial parasites in humans and in animals. It begins by reviewing the current state of diagnosis and chemotherapy, before addressing the increasing resistance to available antifilarial drugs. This is followed by strategies and approaches for the discovery of novel drugs and finally by looking at alternative and supplementary approaches to combat the parasites, including vector control and vaccination.

Local Note:

John Wiley and Sons

Subject Term:

Filariasis.

Filarial worms.

Parasitology.

Parasitic diseases -- Treatment.

Maladies parasitaires -- Traitement.