ch. 1. Clinical pharmacology of SERMs and pure anti-estrogens / Stephen R.D. Johnston -- chapter 2. Aromatase inhibitors : the third generation / William R. Miller -- chapter 3. Systemic therapy of metastatic breast cancer in postmenopausal patients / Carsten Rose. [and others] -- chapter 4. ATAC : early breast cancer / Michael Baum -- chapter 5. Aromatase inhibitors and other agents in early-stage breast cancer / Paul E. Goss and Kathrin Strasser-Weippl -- chapter 6. Neoadjuvant therapy in postmenopausal women / J.M. Dixon -- Panel discussion 1. Therapy in postmenopausal women / Jacques M. Bonneterre and Henning T. Mouridsen -- chapter 7. Endocrine therapy for advanced breast cancer in premenopausal women / Walter Jonat -- chapter 8. Adjuvant endocrine treatment in premenopausal patients / Raimund Jakesz -- chapter 9. Adjuvant chemotherapy in breast cancer patients with hormone-receptor-positive (responsive) disease : focus on premenopausal women / Jonas C.S. Bergh -- Panel discussion 2. Therapy in premenopausal women / Gini F. Fleming and Jan G.M. Klijn -- chapter 10. Biology of premalignant lesions and pathogenesis / D. Craig Allred -- chapter 11. Estradiol-induced carcinogenesis via formation of genotoxic metabolites / Richard J. Santen. [and others] -- chapter 12. Beyond tamoxifen : results of clinical trials / Norman Wolmark -- chapter 13. Clinical trials with aromatase inhibitors for the prevention of breast cancer / Mitch Dowsett -- Panel discussion 3. Chemoprevention / Trevor J. Powles and Wolfgang Eiermann -- chapter 14. Crosstalk between estrogen-receptor and growth-factor-receptor pathways as a mechanism of endocrine therapy resistance / C. Kent Osborne and Rachel Schiff -- chapter 15. ErbB2/HER-2 and other molecular pathways in estrogen-receptor-positive breast cancer : impact on endocrine resistance and clinical outcome / Christopher C. Benz -- chapter 16. Beyond antihormones in the targeted therapy of breast cancer / Robert I. Nicholson. [and others] -- chapter 17. Novel therapeutics / Adrian L. Harris -- chapter 18. Surrogate biomarkers and neoadjuvant endocrine therapy / Matthew J. Ellis -- chapter 19. Aromatase localization in human breast cancer with development of new antibodies / Hironobu Sasano. [and others] -- Panel discussion 4. Biology and new therapeutics / I. Craig Henderson and Manfred Kaufmann -- Panel discussion 5. Final discussion and wrap-up / Adrian L. Harris and C. Kent Osborne.