chapter 1 Vaccines and Vaccination in Historical Perspective / chapter 2 An Overview of Biotechnology in Vaccine Development / chapter 3 Initial Clinical Evaluation of New Vaccine Candidates: Investigators' Perspective of Phase I and Phase II Clinical Trials of Safety, Immunogenicity, and Preliminary Efficacy -- chapter 4 Vaccines Against Respiratory Syncytial Virus and Parainfluenza Virus Types 1–3 / chapter 5 Ethical Considerations in the Conduct of Vaccine Trials in Developing Countries -- chapter 6 Vaccine Economics: From Candidates to Commercialized Products in the Developing World -- chapter 7 Development and Supply of Vaccines: An Industry Perspective / chapter 8 Reaching Every Child—Achieving Equity in Global Immunization / chapter 9 A Paradigm for International Cooperation: The Global Alliance for Vaccines and Immuniztion (GAVI) and the Vaccine Fund -- chapter 10 Economic Analyses of Vaccines and Vaccination Programs / chapter 11 The Role of the Food and Drug Administration in Vaccine Testing and Licensure -- chapter 12 Developing Safe Vaccines / chapter 13 Polio Eradication: Capturing the Full Potential of a Vaccine -- chapter 14 Recent Advances in Immunology that Impact Vaccine Development / chapter 15 High-Throughput Information and In Vitro Assays for T-Cell Epitope Determination: Application to the Design of Epitope-Driven Vaccines -- chapter 16 The Challenge of Inducing Protection in Very Young Infants / chapter 17 Vaccination and Autoimmunity / chapter 18 Adjuvants for the Future / chapter 19 MF59 Adjuvant Emulsion / chapter 20 Immune-Enhancing Sequences (CpG Motifs), Cytokines, and Other Immunomoclulatory Moieties -- chapter 21 Use of Genetically Detoxified Mutants of Cholera and Escherichia Coli Heat-Labile Enterotoxins as Mucosal Adjuvants -- chapter 22 Recent Developments in Vaccine Delivery Systems / chapter 23 Proteosome™ Technology for Vaccines and Adjuvants / chapter 24 Viruslike Particle (VLP) Vaccines / chapter 25 Immunostimulating Reconstituted Influenza Virosomes / chapter 26 Plants as a Production and Delivery Vehicle for Orally Delivered Submit Vaccines -- chapter 27 Vaccinia Virus and Other Poxviruses as Live Vectors / chapter 28 Live Adenovirus Recombinants as Vaccine Vectors / chapter 29 RNA Virus Replicon Vaccines

chapter 30 Attenuated Salmonella and Shigella as Live Vectors Carrying Either Prokaryotic or Eukaryotic Expression Systems -- chapter 31 DNAVaccines -- chapter 32 DNA-Modified Virus Ankara and Other Heterologus Prime-Boost Immunization Strategies for Effector T Cell Induction -- chapter 33 Mucosal Immunization and Needle-Free Injection Devices / chapter 34 Transcutaneous Immunization / chapter 35 Combination Vaccines for Routine Infant Immunization / chapter 36 Meningococcal Conjugate and Protein-Based Vaccines / chapter 37 The Postlicensure Impact of Haemophilus Influenzae Type b and Serogroup C Neisseria Meningitidis Conjugate Vaccines -- chapter 38 Pneumococcal Protein-Polysaccharide Conjugate Vaccines / chapter 39 Pneumococcal Common Proteins and Other Vaccine Strategies / chapter 40 Polysaccharide-Based Conjugate Vaccines for Enteric Bacterial Infections: Typhoid Fever, Nontyphoidal Salmonellosis, Shigellosis, Cholera, and Escherichia coli O157 -- chapter 41 Attenuated Strains of Salmonella Enterica Serovar Typhi as Live Oral Vaccines Against Typhoid Fever -- chapter 42 Vaccines Against Lyme Disease / chapter 43 Oral B Subunit-Killed Whole-Cell Cholera Vaccine / chapter 44 Attenuated Vibrio Cholerae Strains as Live Oral Cholera Vaccines and Vectors -- chapter 45 Novel Vaccines Against Tuberculosis / chapter 46 New Approaches to Influenza Vaccine / chapter 47 Chimeric Vaccines Against Japanese Encephalitis, Dengue, and West Nile / chapter 48 Challenges and Current Strategies in the Development of HIV/AIDS Vaccines -- chapter 49 Vaccine Strategies to Prevent Dengue Fever / chapter 50 Vaccination Against the Hepatitis C Viruses / chapter 51 Live Vaccine Strategies to Prevent Rotavirus Disease / chapter 52 Vaccines Against Respiratory Syncytial Virus and Parainfluenza Virus Types 1-3 -- chapter 53 Developing a Vaccine Against Epstein-Barr Virus / chapter 54 Cytomegalovirus Vaccines / chapter 55 Herpes Simplex Vaccines / chapter 56 Vaccines for Hantaviruses, Lassa Virus, and Filoviruses -- chapter 57 Development of a Vaccine to Prevent Infection with Group A Streptococci and Rheumatic Fever -- chapter 58 Vaccines Against Group B Streptococcus / chapter 59 Overview of Live Vaccine Strategies Against Shigella / chapter 60 Oral Inactivated Whole Cell B Subunit Combination Vaccine Against Enterotoxigenic Escherichia Coli -- chapter 61 Multivalent Shigella/Enterotoxigenic Escherichia Coli Vaccine / chapter 62 Vaccines Against Gonococcal Infection -- chapter 63 Vaccines Against Campylobacter Jejuni / chapter 64 Vaccines Against Uropathogenic Escherichia Coli / chapter 65 Vaccine Strategies Against Helicobacter Pylori

chapter 66 Vaccines for Staphylococcus Aureus Infections / chapter 67 Moraxella Catarrhalis and Nontypable Haemophilus Influenzae Vaccines to Prevent Otitis Media -- chapter 68 Vaccines for Chlamydia Trachomatis and Chlamydia Pneumoniae / chapter 69 Overview of Vaccine Strategies for Malaria / chapter 70 Adjuvanted RTS, S and Other Protein-Based Pre-Erythrocytic Stage Malaria Vaccines -- chapter 71 Malaria: A Complex Disease that May Require a Complex Vaccine / chapter 72 Plasmodium falciparum Asexual Blood Stage Vaccine Candidates: Current Status -- chapter 73 Malaria Transmission-Blocking Vaccines / chapter 74 Vaccines Against Leishmania / chapter 75 Vaccines Against Schistosomiasis / chapter 76 Vaccines Against Entamoeba Histolytica / chapter 77 Vaccines Against Human Hookworm Disease -- chapter 78 Principles of Therapeutic Vaccination for Viral and Nonviral Malignancies / chapter 79 Vaccines Against Human Papillomavirus Infection / chapter 80 Active Immunization with Dendritic Cells Bearing Melanoma Antigens -- chapter 81 Vaccines Against Alzheimer’s Disease -- chapter 82 Vaccines Against Atherosclerosis / chapter 83 Vaccine Therapy / chapter 84 Vaccination-Based Therapies in Multiple Sclerosis / chapter 85 Vaccine Therapy for Autoimmune Diabetes / chapter 86 Vaccines for the Treatment of Autoimmune Diseases / chapter 87 Vaccines to Treat Drug Addiction / chapter 88 Vaccines Against Agents of Bioterrorism / chapter 89 A Primer on Large-Scale Manufacture of Modern Vaccines / chapter 90 Heterogeneity of Pediatric Immunization Schedules in Industrialized Countries.