chapter 1 Introduction -- chapter 2 The History of Therapeutic Trials in Dementia -- chapter 3 Treatment Hypotheses -- chapter 4 Clinical Trial Designs and Endpoint Selection -- chapter 5 The Use of Qualitative Research -- chapter 6 Inclusion and Exclusion Criteria -- chapter 7 Global Assessment Measures -- chapter 8 Cognitive Outcomes -- chapter 9 Functional Outcomes -- chapter 10 Behavioural Outcomes -- chapter 11 Quality of Life Outcomes -- chapter 12 Caregiver Burden Outcomes -- chapter 13 Structural Neuroimaging Outcomes -- chapter 14 Guidelines for Randomised Clinical Studies in Parkinson's Disease with t t t t tDementia and Dementia with Lewy Bodies -- chapter 15 Clinical Trials for Vascular Cognitive Impairment -- chapter 16 Clinical Trials for Primary Prevention in Dementia -- chapter 17 Clinical Trials for Memantine -- chapter 18 Clinical Trials for Psychotropic Agents in Alzheimer's Disease -- chapter 19 Clinical Trials for Psychosocial Interventions Aimed at Caregivers of People t t t t twith Dementia -- chapter 20 Pharmacoeconomic Outcomes -- chapter 21 Executive Dysfunction in Dementia -- chapter 22 Ethical Considerations in the Conduct of Clinical Trials for Alzheimer's t t t t tDisease -- chapter 23 Designs for Trials when there is a Standard Therapy -- chapter 24 Conclusion.