chapter 1 De?nition of Chronic Obstructive Pulmonary Disease / chapter 2 COPD: Worldwide Prevalence / chapter 3 Worldwide Mortality from COPD / chapter 4 Risk Factors for the Development of COPD / chapter 5 Risk Factors for the Progression of COPD / chapter 6 Socioeconomic Burden of COPD / chapter 7 Pathology of COPD / chapter 8 In?ammatory Mechanisms / chapter 9 Defective Repair in COPD: The American Hypothesis / chapter 10 Proteinases in COPD / chapter 11 Oxidative Stress and COPD / chapter 12 Pathogenesis of Infections in COPD Patients / chapter 13 Extrapulmonary Effects of COPD / chapter 14 Smoking Cessation / chapter 15 Anticholinergics / chapter 16 Long-Acting Beta-Adrenoreceptor Agonists for the Treatment of COPD / chapter 17 The Role of Glucocorticosteroids in the Management of COPD / chapter 18 Antibiotics in COPD / chapter 19 Long-Term Intervention Studies: a1-Antitrypsin Substitution / chapter 20 Surgery and Transplantation for COPD / chapter 21 New Therapies for COPD