Preclinical Drug Development

Title:

Author:

Rogge, Mark C., editor.

ISBN:

9780429163210

Edition:

First edition.

Physical Description:

1 online resource (600 pages)

Contents:

The Scope of Preclinical Drug Development: An Introduction and Framework. Interspecies Differences in Physiology and Pharmacology: Extrapolating Preclinical Data to Human Populations. Transgenic Animals for Preclinical Drug Development. Pharmacokinetics/ADME of Small Molecules. Pharmacokinetics/ADME of Large Molecules. Preclinical Pharmacokinetic-Pharmacodynamic Modeling and Simulation. Formulation and Route of Administration - Influencing Drug. Assessment of Pharmacokinetics and Drug Activity: Isolated Organ. Alternate Methods for Assessing Absorption, Metabolism and Routes of Toxicity Evaluations: ICH Guidelines and Current Practice. Application of Pathology in Safety Assessment. Principles of Toxicogenomics: Implications for Preclinical Drug Development. Utilizing the Preclinical Database to Support Clinical Drug Development.

Abstract:

This reference discusses in detail the broad realm of preclinical drug development. Topics range from assessment of pharmacology and toxicology through the regulatory expectations that support clinical trials. Providing chapters on pharmacokinetics, modeling and simulation, formulation and routes of administration, toxicity evaluations.

Subject Term:

Drug development.

Drug Evaluation, Preclinical -- methods.

Drug Industry -- methods.

Genre:

Electronic books.

Added Author:

Rogge, Mark C.,

Taft, David R.,

Added Corporate Author:

Taylor and Francis.

Electronic Access:

Click here to view.

Holds:
Copies:

Available:*

Library	Material Type	Item Barcode	Shelf Number	Status	Item Holds
Searching... Online Library	E-Book	540103-1001	RM301.25 .P745 2005	Searching... Unknown	Searching... Unavailable

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