Overview. pH-responsive nanomedicine for image-guided drug delivery. Enzyme-responsive nanomedicine. Redox-responsive nanomedicine. Hypoxia-responsive nanomedicine. Temperature-responsive nanomedicine. Magnetically responsive nanomedicine. Ultrasound-responsive nanomedicine. Light-triggered drug and gene delivery. Stimuli-responsive liposomes for cancer. Stimuli-responsive nanomedicine for treating non-cancer diseases.