Introduction -- On the fractal nature of evolution -- The historic perspective on paracrinology and evolution as lead-ins to a systems biology approach -- Evolution of adipocyte differentiation related protein, or "Oh, the places you'll go" -- Theodore Geissel, aka Dr Seuss -- Evolutionary ontology and epistemology -- Calcium-lipid epistasis: like Ouroboros, the snake, catching its tail -- The lung alveolar lipofibroblast: an evolutionary strategy against neonatal hyperoxic lung injury -- Bio-logic -- Cell signaling as the basis for all of biology -- Information + Negentropy + Homeostasis = Evolution -- Vertical integration of cytoskeletal function from yeast to human -- Yet another bite of the "evolutionary" apple -- On eliminating the subjectivity from biology: predictions -- The predictive value of the cellular approach to evolution -- Homeostasis as the mechanism of evolution -- On the evolution of development -- A central theory of biology -- Implications of evolutionary physiology for astrobiology -- Pleiotropy reveals the mechanism of evolutionary novelty -- Meta-Darwinism.