Bioprocessing for cell based therapies

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Title:

Author:

Connon, Che J., editor.

ISBN:

9781118743409

9781118743393

Physical Description:

1 online resource

Contents:

Bioprocessing for cell based therapies -- Structured methodology for process development in scalable stirred tank bioreactors platforms -- The effect of scale-up on cell phenotype : compatibility testing to optimize bioreactor usage and manufacturing strategies -- The scale-up of human mesenchymal stem cell expansion and recovery -- Challenges of scale-up of cell separation and purification techniques -- Fundamental points to consider in the cryopreservation and shipment of cells for human application -- Short-term storage of cells for application in cell-based therapies -- Cell therapy in practice.

Abstract:

Bioprocessing for Cell Based Therapies details both existing industrial methods for the large-scale production of a variety of cell types including stem cells, as well as novel recent developments in cell culture from the bioprocessing research community. The book covers fermenter design, 2D and 3D systems, and carrier materials, as well as growth media and conditions. Issues around the supply chain are examined, including current best practice and novel means currently under development. Finally, how the cells are delivered to the patient, within a clinical setting, is discussed.

Contributing authors have been drawn from both academic leaders in the field as well as from experienced industrial partners, ensuring that the book covers both new and applied areas within bioprocessing for cell-based therapies.

This book is aimed at those at the cutting edge of bioprocessing of cell based therapeutics, both within industry and academia, as well as serving as an introduction to the subject for those who are looking to gain a foothold in this rapidly developing and exciting area of medicine.

Che J. Connon is a Professor of Tissue Engineering at the Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. His research interests lie in the design and application of innovative bio-materials to regenerative medicine and bio-processing. --Book Jacket.

Local Note:

John Wiley and Sons

Subject Term:

Cell culture.

Biochemical engineering.

Cell Culture Techniques

Cells, Cultured

Cell- and Tissue-Based Therapy