Clinical manual of blood and bone marrow transplantation

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Title:

Author:

Abutalib, Syed A., editor.

ISBN:

9781119095460

9781119095491

9781119095477

Physical Description:

1 online resource

Contents:

Title Page ; Copyright Page; Contents; Contributors; Preface; Chapter 1 Donor and graft selection strategy; Introduction; What are the donor options?; What are the graft sources?; Donor options; HLA matching for donor selection; HLA matching of UCB; HLA antibodies; How is DSA tested?; Graft composition; PB graft; BM graft; Why is BM graft is preferred in children with hematologic malignancies?; UCB graft; Which graft type should I use?; Non-HLA factors ; What if more than one HLA-matched donor is available? ; Summary; Abbreviations; Selected reading; Chapter 2 HLA typing and implications.

IntroductionHLA nomenclature and tissue typing techniques; Polymorphism; Unrelated donor search and tools for donor search and selection; HLA typing for donor search; The donor search; Classical HLA alleles: Impact of mismatching; Non-classical HLA alleles and matching techniques: Impact on outcomes ; Summary; Selected reading; Chapter 3 Risk-benefit assessment in allogeneic hematopoietic transplant: Factors, scores, and models ; Introduction; What are the factors to consider prior to HCT?; Age; Performance status; Socioeconomic status; Race; Organ function.

Models used for risk-benefit measurement Models estimating incidences of NRM; Models estimating relapse risk; Models estimating all-cause mortality ; How to evaluate a patient for fitness for HCT; Guidelines on pretransplantation data gathering; Summary and practice points for eligibility for HCT; Acknowledgments; Conflict of interest; Selected reading; Chapter 4 Donor and recipient pre-transplant evaluation; Introduction; Donor infectious evaluation; History; Physical examination; Laboratory testing; Management; Special consideration for potentially unsafe products.

Donor non-infectious evaluation History; Physical examination; Laboratory testing; Instrumental investigations; Special consideration for female donors of child-bearing age group; Recipient infectious evaluation; History; Physical examination; Laboratory testing; Management; Recipient non-infectious evaluation ; Assessment of disease type and status; Assessment of functional status and comorbidities; Assessment of psychosocial, financial, and caregiver issues; Summary; Selected reading; Chapter 5 Autologous and allogeneic progenitor cell mobilization; Introduction; Autologous mobilization.

When to use plerixaforWhat if CD34+ cell mobilization fails?; Some practical aspects of autologous CD34+ cell mobilization; Allogeneic CD34+ cell mobilization; What is the best CD34+ cell mobilization regimen for allogeneic healthy volunteer donors?; What is the optimal PB CD34+ cell dose for allogeneic hematopoietic cell transplantation?; High yield points; Selected reading; Chapter 6 Hematopoietic stem and progenitor cell collection by apheresis: Techniques and tricks ; Introduction; Collection techniques and devices used; Technical/clinical aspects of HPC (A) collections; Vascular access.

Abstract:

Providing the practicing and trainee hematologist with a practical and immediately applicable compendium of answers the Clinical Manual of Blood and Bone Marrow Transplantation covers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant program. Supplies the practicing and trainee hematologist with a practical and immediately applicable compendium of answers to clinical questions Covers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant program Contains concise chapters written with a focus on tables, algorithms and figures to aid rapid referral Benefits from expert contributions from an international authorship.

Local Note:

John Wiley and Sons

Subject Term:

Bone marrow -- Transplantation.

Hematopoietic Stem Cell Transplantation

Bone Marrow Transplantation

Moelle osseuse -- Greffe.

MEDICAL -- Surgery -- General.

Hematology.

MEDICAL.

Bone marrow -- Transplantation

Genre: