Structure and function. Structure and function. Morphology and function of the cruciate ligaments / Hilde de Rooster, Eithne Comerford -- Biomechanics of the cruciate ligaments / Susannah J Sample -- Cruciate ligament remodeling and repair / Connie S Chamberlain, Erin E Crowley, Ray Vanderby -- Meniscal structure and function / Antonio Pozzi, James L Cook -- Biomechanics of the normal and cranial cruciate ligament-deficient stifle / Antonio Pozzi, Stanley E Kim -- Etiopathogenesis of cruciate ligament rupture -- Etiopathogenesis of cruciate ligament rupture. Histology of cruciate ligament rupture / Kei Hayashi -- Genetics of cruciate ligament rupture / Lauren A Baker, Peter Muir -- Cruciate ligament matrix metabolism and development of laxity / Eithne Comerford -- Morphological risk factors for cruciate ligament rupture / Eithne Comerford -- Role of nitric oxide production and matrix protease activity in cruciate ligament degeneration / David E Spreng, Simone Forterre -- Role of antibodies to collagen type I and II / Hilde de Rooster, Eithne Comerford -- Synovitis precedes stifle instability associated with cruciate ligament rupture / Jason A Bleedorn -- Role of synovial immune responses in stifle synovitis / Peter Muir -- Clinical features -- Clinical features. Epidemiology of cruciate ligament rupture / Lauren A Baker, Peter Muir -- History and clinical signs of cruciate ligament rupture / Peter Muir -- Partial rupture of the cranial cruciate ligament / Peter Muir -- Caudal cruciate ligament rupture / Peter Muir -- Stress imaging of the stifle / Stanley E Kim -- Stifle ultrasonography / Cristi R Cook -- Computed tomography (CT) of the stifle / Ingrid Gielen, Henri van Bree -- Magnetic resonance imaging of the stifle / Peter V Scrivani -- Risk prediction of cruciate ligament rupture using stifle diagnostic imaging / Peter Muir -- Surgical treatment -- Surgical treatment. Arthroscopy and arthrotomy of the stifle / Brian S Beale, Donald A Hulse, Antonio Pozzi, Peter Muir -- Joint lavage / Peter Muir -- Extracapsular stabilization / Selena Tinga, Stanley E Kim -- Intra-articular repair for cranial cruciate ligament rupture in the dog / Jeffery J Biskup, Michael G Conzemius -- Tibial plateau leveling osteotomy / Susan L Schaefer -- Tibial tuberosity advancement / Randy J Boudrieau -- Closing cranial wedge ostectomy and triple tibial osteotomy / Simon C Roe -- Treatment of excessive tibial plateau angle / Michael P Kowaleski -- Surgical management of cruciate ligament rupture combined with patella luxation / Anke Langenbach, Denis J Marcellin-Little -- Biomechanics of the cranial cruciate ligament-deficient stifle treated by tibial osteotomies / Antonio Pozzi, Stanley E Kim, Selena Tinga -- Arthroscopic follow-up after surgical stabilization of the stifle / Brian S Beale, Donald A Hulse -- Cranial cruciate ligament debridement / David E Spreng -- Surgical treatment of concurrent meniscal injury / Samuel P Franklin, James L Cook, Antonio Pozzi -- Meniscal release / Antonio Pozzi, James L Cook -- Progression of osteoarthritis after stifle stabilization surgery / Susannah J Sample -- Clinical outcomes after surgical treatment of cruciate ligament rupture / Mary Sarah Bergh, Steven C Budsberg -- Success and failure after stifle stabilization surgery / Michael G Conzemius, Richard B Evans -- Diagnosis and management of orthopaedic infection after stifle surgery / Noël MM Moens -- Medical management of cruciate ligament rupture -- Medical management of cruciate ligament rupture. Medical therapy for stifle osteoarthritis / Steven C Budsberg -- Rehabilitation for dogs with cruciate ligament rupture / Denis J Marcellin-Little, Courtney J Arnoldy -- Future directions -- Future directions. Clinical research design and patient-oriented outcomes / Dorothy Cimino Brown -- Total knee replacement in the dog / Matthew J Allen, William D Liska, Valentina Brioschi -- Regenerative medicine and cranial cruciate ligament repair / Gabriel S Perrone, Martha M Murray, Patrick Vavken -- Disease-modifying medical and cell-based therapy / Susannah J Sample, Peter Muir.