Neglected tropical diseases : drug discovery and development

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Title:

Author:

Swinney, David Carl, editor.

ISBN:

9783527808656

9783527808625

Physical Description:

1 online resource

Series:

Methods and principles in medicinal chemistry ; volume 79

Methods and principles in medicinal chemistry ; v. 79.

Contents:

Drug Discovery Strategies for Neglected Tropical Diseases: Repurposing Knowledge, Mechanisms and Therapeutics to Increase Discovery Efficiency / David C Swinney, Michael P Pollastri -- Virus. Toward Antiviral Therapies for the Treatment of Zika Virus Infection: Lessons Learned from Dengue Virus / Sarah K Stevens*, Paul C Jordan*, Andreas Jekle, Jerome Deval -- Developing Therapeutics for Ebola Virus Disease: A Multifaceted Approach / Michael K Lo, Jessica R Spengler, Bobbie Rae Erickson, Christina F Spiropoulou -- Kinetoplastids. Designing Drugs to Target Trypanosoma cruzi, the Etiological Agent of Chagas Disease: When Chemistry needs Biology / Martine Keenan, Eric Chatelain -- Drug Discovery and Development for Human African Trypanosomiasis / Andrew Spaulding, Mitchell F Gallerstein, Lori Ferrins -- Discovery of Drugs for Leishmaniases: A Progress Report / Baljinder Singh, Frederick S Buckner, Michael P Pollastri -- Helminths. Onchocerciasis Drug Discovery / Natalie A Hawryluk, Ivan Scandale -- Drug Discovery and Development for Schistosomiasis / Conor R Caffrey, Nelly El-Sakkary, Patrick Mäder, Reimar Krieg, Katja Becker, Martin Schlitzer, David H Drewry, Jonathan L Vennerstrom, Christoph G Grevelding -- Soil-transmitted Helminthiasis -- Challenges with Discovery of Novel Anthelmintics / Graham M Kyne, Michael P Curtis, Jennifer Keiser, Debra J Woods -- Drug Discovery and Development for the Treatment of Echinococcosis, Caused by the Tapeworms Echinococcus granulosus and Echinococcus multilocularis / Andrew Hemphill, Reto Rufener, Dominic Ritler, Luca Dick, Britta Lundström-Stadelmann -- New Insights into the Treatment of Foodborne Trematode Infections / Rafael Toledo, Alba Cortés, Maria Álvarez-Izquierdo, Carla Muñoz-Antoli, J Guillermo Esteban -- Bacteria. Buruli Ulcer / Nicole Scherr, Gerd Pluschke -- Drug Discovery and Development for Leprosy / Carlos Franco-Paredes.

Abstract:

A drug discovery reference to the crippling tropical diseases that affect more than 1 billion people. Neglected Tropical Diseases is the first book of its kind to offer a guide that follows the World Health Organization?s list of neglected tropical diseases. The authors?all are experts on the topic?address the development of effective treatments for 12 crippling infectious diseases that affect almost 20% of the world?s popluation. The book includes information on the common approaches and the most important factors that lead to the development of new drugs for treating tropical diseases. Individual chapters review 12 neglected tropical diseases that are grouped by infectious agent, from viruses to bacteria to eukaryotic parasites. For each of these diseases, the book explains the unmet medical need and explores the current and potential drug discovery strategies. The book also includes information on potential drug compounds derived from natural products. This important book: -Ties together information from different sources for developing novel treatsments forneglected tropical diseases -Is aligned with WHO?s initiative to eradicate tropical diseases -Outlines current and potential drugs for treating tropical diseases -Provides a standard reference for the entire field Written for medicinal chemists, pharmaceutical chemists, pharmaceutical industry, virologists, parasitologists, and specialists on tropics medicine, Neglected Tropical Diseases offers an essential guide and a systematic reference for the development of successful treatments for 12 crippling infectious diseases.

Local Note:

John Wiley and Sons

Subject Term:

Tropical medicine.

Drug development.

Tropical Medicine -- methods

Neglected Diseases -- drug therapy

Médicaments -- Développement.