Title:
Bioadhesives in drug delivery
Author:
Mittal, K. L., 1945- editor.
ISBN:
9781119640240
9781119640264
9781119640257
Edition:
First edition.
Physical Description:
1 online resource
Series:
Adhesion and Adhesives: Fundamental and Applied Aspects
Adhesion and adhesives.
Contents:
Theories and Mechanisms of Bioadhesion 3; Kamla Pathak and Rishabha Malviya 1.1 Introduction 4 1.1.1 Historical Perspective 4 1.1.2 Bioadhesion in Biological Systems 5 1.1.3 Bioadhesive/Mucoadhesive 6 1.1.4 Factors Affecting Mucoadhesion 6 1.1.4.1 Molecular Weight of Polymer 6 1.1.4.2 Concentration of Polymer Used 7 1.1.4.3 Flexibility of Polymer Chains 7 1.1.4.4 Swelling 7 1.1.4.5 pH at Polymer-Mucus Interface 7 1.1.4.6 Mucin Turnover Rate 7 1.1.4.7 Stereochemistry 7 1.2 Bioadhesive Interactions 8 1.3 The Mechanistic Approach to Bioadhesion 9 1.4 Factors Controlling Bioadhesion 10 1.4.1 Chemical Interactions 10 1.4.1.1 Mussel Adhesion 10 1.4.1.2 Cell Adhesion to Biomaterials 11 1.4.2 Surface Morphology Effects 11 1.4.3 Physiological Factors 12 1.4.4 Physical and Mechanical Factors 12 1.4.4.1 Wetting Phenomenon 12
1.4.4.2 Interpenetration 12 1.5 Theories of Bioadhesion 13 1.5.1 Wetting Theory 13 1.5.2 Diffusion Theory 15 1.5.3 Electronic Theory 16 1.5.4 Adsorption Theory 16 1. 5.5 Fracture Theory 16 1.6 Stages of Mucoadhesion 17 1.7 Modulation of Mucoadhesion 18 1.8 Adhesion Promoters 19 1.9 Surface Free Energy Analysis of Bioadhesion 19 1.10 Molecular Biology in Bioadhesion 20 1.11 Bioadhesives from Marine Sources 21 1.12 Mucoadhesive Drug Delivery Systems 22 1.13 Summary 23 References 23 2 Bioadhesive Polymers for Drug Delivery Applications 29; Kenneth Chinedu Ugoeze 2.1 Introduction 30 2.1.1 Drug Delivery 30 2.2 Bioadhesive/Mucoadhesive Drug Delivery Systems 31 2.2.1 Some Advantages of Bioadhesive/Mucoadhesive Drug Delivery Systems 32 2.2.2 The General Need for Bioadhesive/Mucoadhesive Drug Delivery Systems 33 2.3
Ex Vivo and In Vivo Methods for Characterization of Bioadhesiveness of Drug Delivery Systems 57; Ljiljana Djekic and Martina Martinovic 3.1 Introduction 58 3.2 Mechanisms of Bioadhesion 59 3.3 Bioadhesive Drug Delivery Systems (BDDS) 62 3.3.1 BDDS for Cutaneous Application 62 3.3.2 BDDS for Buccal Application 63 3.3.3 BDDS for Peroral Application 64 3.3.4 BDDS for Vaginal Application 65 3.3.5 BDDS for Nasal Application 66 3.3.6 BDDS for Ocular Application 67 3.4 Methods for Testing Bioadhesive Property of BDDS 68 3.4.1 In Vitro/Ex Vivo Tests 68 3.4.1.1 Bioadhesion Strength Tests 68 3.4.1.2 In Vitro Methods for Characterization of Bioadhesion at the Molecular Level 81 3.4.2 In Vivo Methods 85 3.4.2.1 Radiolabelled BDDS Transit Studies 86 3.4.2.2 Gamma Scintigraphy 87 3.4.2.3 In Vivo Detachment Tests 87 3.5
Solvent Casting 111 4.5.2 Extrusion 111 4.5.3 Rolling 111 4.5.4 2D Printing 112 4.6 Evaluation of Bioadhesive Films 113 4.6.1 Bioadhesive Strength 113 4.6.2 Tensile Strength Measurement 114 4.6.3 Morphology and Thickness 114 4.6.4 Moisture Content 114 4.6.5 Permeation 115 4.6.6 Swelling 116 4.6.7 Irritation 116 4.6.8 Stability 116 4.6.9 Drug Loading and Drug Entrapment Efficiency 117 4.7 Summary 117 4.8 Acknowledgements 118 References 118 5 Redox-Responsive Disulphide Bioadhesive Polymeric Nanoparticles for Colon-Targeted Drug Delivery 123; Erazuliana Abd Kadir and Vuanghao Lim 5.1 Introduction 123 5.2 Mechanism of Disulphide Bond Formation 124 5.3 Disulphide Polymers for Colon Drug Delivery 125 5.4 Colon-Targeted Drug Delivery (CTDD) 126 5.4.1 Condition of the Colon for Drug Delivery 127 5. 4.2
Abstract:
"Understanding the phenomenon of bioadhesion i.e. its theories or mechanism(s) are of critical importance in developing optimum bioadhesive polymers (used in bioadhesives). Such bioadhesive polymers are the key for exhibiting the process of bioadhesion, controlled/sustained release of drugs, and drug targeting. The use of bioadhesives restricts the delivery system to the site of interest and thus offers a useful and efficient technique for targeting a drug to the desired location for a prolonged duration. This book addresses the various relevant aspects of bioadhesives in drug delivery in an easily accessible and unified manner. The book containing 12 chapters written by eminent researchers from many parts of the globe is divided into three parts: Part 1: Fundamental Aspects; Part 2: Bioadhesive Formulations; Part 3: Drug Delivery Applications. The topics covered include: Theories and mechanisms of bioadhesion; bioadhesive polymers for drug delivery applications; methods for characterization of bioadhesiveness of drug delivery systems; bioadhesive films and drug delivery applications; bioadhesive nanoparticles; and bioadhesive hydrogels and applications ocular biodhesive drug delivery systems; buccal bioadhesive drug delivery systems; gastrointestinal bioadhesive drug delivery systems ; nasal bioadhesive drug delivery systems; vaginal drug delivery systems; pulmonary bioadhesive drug delivery systems"-- Provided by publisher
Local Note:
John Wiley and Sons
Genre:
Added Author:
Electronic Access:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781119640240Copies:
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