Cover image for Multicomponent reactions towards heterocycles : concepts and applications
Title:
Multicomponent reactions towards heterocycles : concepts and applications
Author:
Eycken, Erik van der, editor.
ISBN:
9783527832439
Physical Description:
1 online resource
Contents:
Heterocycles as Inputs in MCRs : An Update / Ouldouz Ghashghaei, Marina Pedrola, Carmen Escolano, Rodolfo Lavilla -- Heterocycles and Multicomponent Polymerizations / Susan Sieben, Jordy M Saya, Dean Johnson, Romano VA Orru -- Multicomponent Reactions in Medicinal Chemistry / Zefeng Wang, Alexander Domling -- Solid-Phase Heterocycle Synthesis Using Multicomponent Reactions / Leonardo G Ceballos, Daylin F Pacheco, Bernhard Westermann, Daniel G Rivera -- Green Synthesis of Heterocycles Via MCRs / Wei Zhang -- The Use of Flow Chemistry in the Multicomponent Synthesis of Heterocycles / Chiara Lambruschini, Lisa Moni, Andrea Basso -- C-H Functionalization as an Imperative Tool Toward Multicomponent Synthesis and Modification of Heterocycles / Alexey A Festa, Leonid G Voskressensky -- Multicomponent-Switched Reactions in Synthesis of Heterocycles / Valentyn A Chebanov, Serhiy M Desenko, Victoria V Lipson, Nikolay Yu Gorobets -- Recent Applications of Multicomponent Reactions Toward Heterocyclic Drug Discovery / Nathan Bedard, Alessandra Fistrovich, Kevin Schofield, Arthur Shaw, Christopher Hulme -- Multicomponent Syntheses of Heterocycles by Catalytic Generation of Alkynoyl Intermediates / Jonas Niedballa, Thomas JJ Mller -- Synthesis of Saturated Heterocycles via Multicomponent Reactions / Carlos KZ Andrade, Carlos EM Salvador, Thaissa PF Rosalba, Luclia ZA Correa, Luan A Martinho, Yuri RB Sousa -- Multicomponent Reactions and Asymmetric Catalysis / Melody E Botius, Eelco Ruijter -- Recent Trends in Metal-catalyzed MCRs Toward Heterocycles / Lilia Fuentes-Morales, Luis D Miranda.
Abstract:
Presents a wide-ranging overview of essential topics and recent advances in MCR chemistry Heterocycles are a central component in natural product chemistry, pharmaceuticals, agrochemicals, and material science. New synthetic methodologies integrating the sequencing of multicomponent reactions (MCRs) are today being used for the rapid synthesis of diversified heterocycles in just one step. Multicomponent Reactions towards Heterocycles presents an up-to-date summary MCR chemistry with a focus on the conjugation between modern synthetic methodologies and MCRs. Featuring contributions by leaders in the field, this comprehensive resource highlights applications of MCRs in natural products and intermediate synthesis, discusses current trends and future prospects in MCR chemistry, outlines novel multicomponent procedures, and more. The authors provide the practical information required for designing new reaction strategies and mechanisms, covering topics including MCR-based green synthetic methods, cyclization and cycloaddition reactions, heterocycle multicomponent syntheses in a continuous flow, catalytic alkynoyl generation, MCR synthesis of saturated heterocycles, and C-H functionalization and multicomponent reactions. * Provides a thorough overview ofheterocycles as input in multicomponent reactions * Discusses recent advances in the field of MCR chemistry and progress in the synthesis and functionalization of heterocycles * Demonstrates the use of MCRs to simplify synthetic design and achieve complexity and diversity in novel bioactive molecules * Highlights examples of multicomponent polymerizations, target-oriented synthesis, and applications of MCR in medicinal chemistry * Explains the methodology of using on-resin MCRs to produce heterocycle compounds Illustrating the key role of MCRs towards heterocycles in natural product synthesis, drug discovery, organic synthesis, and other applications, Multicomponent Reactions towards Heterocycles is required reading for synthetic chemists in academia and industry alike.
Local Note:
John Wiley and Sons
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