Drug transporters : molecular characterization and role in drug disposition

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Title:

Author:

You, Guofeng, editor.

ISBN:

9781119739883

9781119739876

9781119739869

Uniform Title:

Drug transporters (2007)

Edition:

Third edition.

Physical Description:

1 online resource (xxii, 552 pages) : illustrations (chiefly color).

Series:

Wiley series in drug discovery and development

Wiley series in drug discovery and development.

Contents:

Overview of drug transporter families / Guofeng You and Marilyn E. Morris -- Organic Cation and Zwitterion transporters / Megan L. Koleske, Xiaomin Liang, Osatohanmwen Jessica Enogieru, Dina Buitrago, and Kathleen M. Giacomini -- Multidrug and toxin extrusion proteins / Lauren M. Aleksunes, Victoria Woo, and Melanie S. Joy -- Organic anion transporters (OATs) / Jeffry C. Granados, Jingui Zhang, Guofeng You, Sanjay K. Nigam -- Organic anion transporting polypeptides OATP / Rommel G. Tirona and Richard B. Kim -- Mammalian oligopeptide transporters / Stephen M. Carl, Dea Herrera-Ruiz, Rajinder K. Bhardwaj, Olafur Gudmundsson, Stephanie Mowery, and Gregory T. Knipp -- Monocarboxylic acid transporters / Marilyn E. Morris and Nisha V. Kwatra -- The nucleoside transporters CNTs and ENTs / Raj Govindarajan, Antonio López Quiñones, and Joanne Wang -- Bile acid transporters / Ebehiremen N. Ayewoh and Peter W. Swaan -- The P-glycoprotein multidrug transporter / Andaleeb Sajid, Sabrina Lusvarghi and Suresh V. Ambudkar -- Multidrug resistance proteins of the ABCC subfamily / Anne T. Nies and Franziska Klein -- ABCG2, the breast cancer resistance protein (BCRP) / Robert W. Robey, Sabrina Lusvarghi, Cindy H. Chau, Agnes Basseville, William D. Figg, Suresh V. Ambudkar, and Susan E. Bates -- Drug transport in the liver / Noora Sjöstedt, Jeffry Adiwidjaja, William A. Murphy, and Kim L.R. Brouwer -- Drug transport in the brain / Vishal Sangha, Erica I. Williams, Patrick T. Ronaldson, and Reina Bendayan -- Drug transport in the kidney / Douglas H. Sweet -- Drug transporters in the human intestine / Stefan Oswald -- Drug transport in the placenta / Qingcheng Mao, Vadivel Ganapathy, and Jashvant D. Unadkat -- Polymorphisms of drug transporters and clinical relevance / Tore B. Stage and Deanna L. Kroetz -- Ontogeny of drug transporters / Melanie A. Felmlee and Qing Zhang -- Experimental approaches for studying drug transporters / Yusuke Masuo, Azusa Futatsugi, and Yukio Kato -- Transporters mediated drug disposition : physiochemistry and in silico approaches / Manthena V. S. Varma, Ayman El-Kattan, and Yurong Lai -- In vitro-in vivo scale-up of drug transport activities / Kazuya Maeda and Yuichi Sugiyama -- Application of physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) modeling comprising transporters : delineating the role of various factors in drug disposition and toxicity / Matthew D. Harwood, Amin Rostami-Hodjegan, and Sibylle Neuhoff -- Transporters as therapeutic targets in human diseases / Robert S. Jones and Eugene C. Chen -- Diet/nutrient interactions with drug transporters / Marilyn E. Morris and Tianjing Ren.

Abstract:

"Unique in the field of pharmaceutical science, this revised 3rd edition takes into account that knowledge in transporters as drug targets for diseases has expanded. Since publication of the second edition, there have been significant advances in the field: in-depth understanding of membrane transporters in pediatric pharmacotherapy, new insights into the impact of these transporters on drug efficacy and safety, and more sophisticated model systems and sensitive assay methods that have been developed. This edition considers the current advances in the field and includes new chapters on in vitro-in vivo scale-up of drug transport activities, the ontogeny of drug transporters, and the transporters as therapeutic targets for diseases. With newly emerging discoveries in transporter science, this book offers both fundamental and updated knowledge of drug transporters. As a result, this new edition reflects where the field is today and also gives a perspective on the directions for the foreseeable future"-- Provided by publisher.

Local Note:

John Wiley and Sons

Subject Term:

Carrier proteins.

Drug carriers (Pharmacy)

Pharmacokinetics.

Biological Transport -- physiology

Membrane Transport Proteins

Pharmacokinetics

Carrier Proteins

Protéines de transport membranaire.

Pharmacocinétique.