An overview of G protein coupled receptors and their signaling partners -- Recent advances in orphan GPCRs research and therapeutic potential -- The Evolution of Our Understanding of GPCRs -- Approaching GPCR dimers and higher order oligomers using biophysical, biochemical and proteomic methods -- Arrestin and G protein interactions with GPCRs : a structural perspective -- GPCRs at endosomes : sorting, signaling, and recycling -- Post-translational Control of GPCR Signaling -- GPCR Signaling from Intracellular Membranes -- Ten years of GPCR structures -- Activation of class B GPCR by peptide ligands : general structural aspects -- Dynamical basis of GPCR-G-protein coupling selectivity and promiscuity -- Virtual Screening and Bioactivity Modeling for G Protein-Coupled Receptors -- Importance of structure and dynamics in the rational drug design of G protein-coupled receptor (GPCR) modulators -- Signaling, Physiology and Targeting of GPCR-Regulated Phospholipase C Enzymes -- G Protein-coupled Receptors in Metabolic Disease -- Endothelin Receptors in cerebrovascular diseases -- The calcium-sensing receptor (CaSR) in disease -- G protein-coupled receptors and their mutations in cancer : a focus on adenosine receptors -- Dopamine Receptors: Neurotherapeutic Targets for Substance Use Disorders -- PTHR1 in bone -- Activators of G-protein Signaling in the normal and diseased kidney -- Screening and characterization of GPCR-ligand interactions with mass spectrometry-based technologies -- Bioluminescence resonance energy transfer (BRET) technologies to study GPCRs -- The Application of 19F NMR to Studies of Protein Function and Drug Screening -- Chapter X : Optical Approaches for Dissecting GPCR Signaling -- GPCR Signaling in Nanodomains : Lessons from Single-Molecule Microscopy.