Cover -- Title Page -- Copyright Page -- Contents -- Foreword -- Preface -- List of Acronyms -- About the Companion Website -- Introduction -- Chapter 1 Compounding Regulations -- Organizations and Regulatory Agencies Involved with Compounding -- Food and Drug Administration -- United States Pharmacopeia -- Drug Enforcement Administration -- State Boards of Pharmacy -- State Veterinary Boards -- Compliance Policy Guides and Guidance for Industry Documents -- What Is Compounding? -- The Food, Drug, and Cosmetic Act -- Animal Medicinal Drug Use Clarification Act -- Preparing Compounds from an Approved Product or a Pure Drug Powder -- Federal Versus State Law [8] -- Office Use Compounding -- Drug Quality and Security Act [26] -- Finding Additional Information -- References -- Chapter 2 Risk-Benefit Analysis of Compounded Medications -- Benefits of Compounded Products -- Dosage Form -- Flavoring -- Dosage Strength -- Eliminating Ingredients -- Availability Issues -- Appropriate Use of Compounded Medications -- FDA-Approved Drugs -- Compounded Medication Risks -- Compounded (USP) Versus Manufactured (cGMP) -- Risks Associated with Compounded Medications - A Look at the Literature -- Studies Showing Incorrect Potency -- Studies Showing Lack of Stability -- Studies Showing Lack of Efficacy -- Risks Associated with Specific Types of Compounds -- Active Ingredient Source Decisions -- Patient-Specific Compounding Versus Office Use Compounding -- Adverse Event Reporting -- Identifying Potential Formulation Issues -- Drugs Recalls -- Selecting a Compounding Pharmacy -- Client Education -- Reducing Risk in Practice -- Conclusion -- References -- Chapter 3 Beyond-Use Dating -- Factors Considered When Assigning BUDs and Expiration Dates -- USP Default BUDs -- Stability Studies -- Evaluating Stability Studies -- Determining BUDs for In-House Formulations.

BUD Considerations When Prescribing Compounded Medications -- Conclusion -- References -- Chapter 4 Identifying High-Quality Compounding Pharmacies -- Case Study 1 -- Case Study 2 -- What to Evaluate -- General Practices -- Staff Skill Level -- Familiarity with Veterinary Medicine -- Pharmacy Culture -- Ways to Evaluate Compounding Pharmacies -- Looking Beyond the Pharmacy's Website -- What to Look for on a Tour -- Questions to Ask the Pharmacist in Charge -- Conclusion -- References -- Chapter 5 Formulation Development -- Dosage Forms -- Oral Administration -- Transdermal Administration -- Topical Administration -- Otic Administration -- Other Routes of Administration -- Ingredients -- Organic Salts -- Inorganic Salts -- Oral Liquid Medications -- Oral Solid Medications -- Emulsions -- Transdermal Medications -- Cream, Gel, and Ointment Medications -- Hazardous Drugs -- Beyond-Use Dates -- Formulation Resources -- Calculations -- Measurements Used in Compounding -- Displacement Factor -- Capsules: Packing Statistics -- Packing Statistic of Drug -- Average Weight of Ingredients -- Percentage of Drug per Capsule Using Bulk Powder -- Percentage of Drug per Capsule Using Manufactured Tablet -- Percentage/Amount of Filler per Capsule -- Conversion to Grams -- Compounding Formulations to Avoid -- Formulation Development Process -- Developing a Compounding Formula: Example 1 (USP Compounding Compendium) -- Developing a Compounding Formula: Example 2 (Stability-Indicating Assay) -- Compounding Formulation Assessment -- References -- Chapter 6 Compounding in House -- Documentation -- Master Formulation Record -- Compounding Record -- Formulation Record Components -- Quality Assurance and Quality Control -- Labeling -- Packaging and Storage -- Compounding Techniques -- Trituration -- Sifting -- Geometric Dilution -- Wetting -- Colored Tracers -- Equipment.

Mortars and Pestles -- Glassware -- Containers -- Scales -- Spatulas and Measuring Devices -- Equipment Cleaning -- Training -- Formulation Instructions -- Species-Specific Information -- Flavoring -- Toxicities -- Potency Designations -- Feasibility for a Veterinary Clinic -- References -- Index -- EULA.