Transplantation and Mechanical Support for End-Stage Heart and Lung Disease addresses the medical and surgical treatment options for patients with end-stage heart and lung disease. All facets of these complex and resource-intensive therapies are covered by leading experts - including the basics of transplant immunology, databases, regulatory and ethical aspects of transplantation and conventional and new modalities of donor organ harvest. Transplantation and Mechanical Support for End-Stage Heart and Lung Disease includes further information on topics such as: Historical developments that facilitated heart and lung transplantation; engineering advances in continuous flow technologies; Transplant organizations, oversight, structure, process, databases and registries in the thoracic transplants and MCS field; Current strategies in immune modulation, desensitization protocols and mechanisms of allograft rejection and tolerance/immunosenescence; Detailed descriptions of donor and recipient surgical procedures as well as comprehensive implantation techniques for all available short- and long-term mechanical circulatory support devices, including ECMO; and Organ allocation and prioritization, donor evaluation, high risk donors, marginal donors, and risk assessment.